SYNAPSE: An international roadmap to large brain imaging

Anton P.J. Stampfl; Zhongdong Liu; Jun Hu; Kei Sawada; H. Takano; Yoshiki Kohmura; Tetsuya Ishikawa; Jae Hong Lim; Jung Ho Je; Chian Ming Low; Alvin Teo; Eng Soon Tok; Tin Wee Tan; Kenneth Ban; Camilo Libedinsky; Francis Chee Kuan Tan; Kuan Peng Chen; An Cheng Yang; Chao Chun Chuang; Nan Yow Chen; Chi Tin Shih; Ting Kuo Lee; De Nian Yang; Hsu Chao Lai; Hong Han Shuai; Chang Chieh Cheng; Yu Tai Ching; Chia Wei Li; Ching Che Charng; Chung Chuan Lo; Ann Shyn Chiang; Benoit Recur; Cyril Petibois; Chia Liang Cheng; Hsiang Hsin Chen; Shun Min Yang; Yeukuang Hwu; Catleya Rojviriya; Supagorn Rugmai; Saroj Rujirawat; Giorgio Margaritondo

doi:10.1016/j.physrep.2022.11.003

SYNAPSE: An international roadmap to large brain imaging

Anton P.J. Stampfl, Zhongdong Liu, Jun Hu, Kei Sawada, H. Takano, Yoshiki Kohmura, Tetsuya Ishikawa, Jae Hong Lim, Jung Ho Je, Chian Ming Low, Alvin Teo, Eng Soon Tok, Tin Wee Tan, Kenneth Ban, Camilo Libedinsky, Francis Chee Kuan Tan, Kuan Peng Chen, An Cheng Yang, Chao Chun Chuang, Nan Yow ChenChi Tin Shih, Ting Kuo Lee, De Nian Yang, Hsu Chao Lai, Hong Han Shuai, Chang Chieh Cheng, Yu Tai Ching, Chia Wei Li, Ching Che Charng, Chung Chuan Lo, Ann Shyn Chiang, Benoit Recur, Cyril Petibois, Chia Liang Cheng, Hsiang Hsin Chen, Shun Min Yang, Yeukuang Hwu, Catleya Rojviriya, Supagorn Rugmai, Saroj Rujirawat, Giorgio Margaritondo^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Since 2020, synchrotron radiation facilities in several Asia-Pacific countries have been collaborating in a major project called “SYNAPSE” (Synchrotrons for Neuroscience: an Asia-Pacific Scientific Enterprise). They use x-ray imaging to attack in a coordinated fashion one of the major issues in modern science: the structure of animal and human brains, including neurons and connections. The objective is to develop Google-like maps also including detailed structural and functional information for selected regions of interest. The sheer mass of data needed for the objective poses huge problems for the acquisition, processing, storage and use of images. In order to complete the task within a reasonable time, the key element of the SYNAPSE strategy is the parallel and coordinated work of several facilities on the same specimens. This article reviews different aspects of the enterprise, including the foundations of synchrotron radiation, coherence and of its role in advanced imaging, electron accelerators, x-ray optics and detectors. This will provide the foundation for an extensive presentation of the different components of SYNAPSE, with an overview of results already obtained within the consortium.

Original language	English
Pages (from-to)	1-60
Number of pages	60
Journal	Physics Reports
Volume	999
DOIs	https://doi.org/10.1016/j.physrep.2022.11.003
State	Published - 9 Feb 2023

Keywords

Brain mapping
Phase contrast
Radiology
Supercomputing
Synchrotron
X-rays

Access to Document

10.1016/j.physrep.2022.11.003

Cite this

Stampfl, A. P. J., Liu, Z., Hu, J., Sawada, K., Takano, H., Kohmura, Y., Ishikawa, T., Lim, J. H., Je, J. H., Low, C. M., Teo, A., Tok, E. S., Tan, T. W., Ban, K., Libedinsky, C., Tan, F. C. K., Chen, K. P., Yang, A. C., Chuang, C. C., ... Margaritondo, G. (2023). SYNAPSE: An international roadmap to large brain imaging. Physics Reports, 999, 1-60. https://doi.org/10.1016/j.physrep.2022.11.003

@article{6c60022d70ba4f62aaa9382d4269e6dd,

title = "SYNAPSE: An international roadmap to large brain imaging",

abstract = "Since 2020, synchrotron radiation facilities in several Asia-Pacific countries have been collaborating in a major project called “SYNAPSE” (Synchrotrons for Neuroscience: an Asia-Pacific Scientific Enterprise). They use x-ray imaging to attack in a coordinated fashion one of the major issues in modern science: the structure of animal and human brains, including neurons and connections. The objective is to develop Google-like maps also including detailed structural and functional information for selected regions of interest. The sheer mass of data needed for the objective poses huge problems for the acquisition, processing, storage and use of images. In order to complete the task within a reasonable time, the key element of the SYNAPSE strategy is the parallel and coordinated work of several facilities on the same specimens. This article reviews different aspects of the enterprise, including the foundations of synchrotron radiation, coherence and of its role in advanced imaging, electron accelerators, x-ray optics and detectors. This will provide the foundation for an extensive presentation of the different components of SYNAPSE, with an overview of results already obtained within the consortium.",

keywords = "Brain mapping, Phase contrast, Radiology, Supercomputing, Synchrotron, X-rays",

author = "Stampfl, {Anton P.J.} and Zhongdong Liu and Jun Hu and Kei Sawada and H. Takano and Yoshiki Kohmura and Tetsuya Ishikawa and Lim, {Jae Hong} and Je, {Jung Ho} and Low, {Chian Ming} and Alvin Teo and Tok, {Eng Soon} and Tan, {Tin Wee} and Kenneth Ban and Camilo Libedinsky and Tan, {Francis Chee Kuan} and Chen, {Kuan Peng} and Yang, {An Cheng} and Chuang, {Chao Chun} and Chen, {Nan Yow} and Shih, {Chi Tin} and Lee, {Ting Kuo} and Yang, {De Nian} and Lai, {Hsu Chao} and Shuai, {Hong Han} and Cheng, {Chang Chieh} and Ching, {Yu Tai} and Li, {Chia Wei} and Charng, {Ching Che} and Lo, {Chung Chuan} and Chiang, {Ann Shyn} and Benoit Recur and Cyril Petibois and Cheng, {Chia Liang} and Chen, {Hsiang Hsin} and Yang, {Shun Min} and Yeukuang Hwu and Catleya Rojviriya and Supagorn Rugmai and Saroj Rujirawat and Giorgio Margaritondo",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2023",

month = feb,

day = "9",

doi = "10.1016/j.physrep.2022.11.003",

language = "English",

volume = "999",

pages = "1--60",

journal = "Physics Reports",

issn = "0370-1573",

publisher = "Elsevier B.V.",

}

Stampfl, APJ, Liu, Z, Hu, J, Sawada, K, Takano, H, Kohmura, Y, Ishikawa, T, Lim, JH, Je, JH, Low, CM, Teo, A, Tok, ES, Tan, TW, Ban, K, Libedinsky, C, Tan, FCK, Chen, KP, Yang, AC, Chuang, CC, Chen, NY, Shih, CT, Lee, TK, Yang, DN, Lai, HC, Shuai, HH , Cheng, CC , Ching, YT, Li, CW, Charng, CC, Lo, CC, Chiang, AS, Recur, B, Petibois, C, Cheng, CL, Chen, HH, Yang, SM, Hwu, Y, Rojviriya, C, Rugmai, S, Rujirawat, S & Margaritondo, G 2023, 'SYNAPSE: An international roadmap to large brain imaging', Physics Reports, vol. 999, pp. 1-60. https://doi.org/10.1016/j.physrep.2022.11.003

TY - JOUR

T1 - SYNAPSE

T2 - An international roadmap to large brain imaging

AU - Stampfl, Anton P.J.

AU - Liu, Zhongdong

AU - Hu, Jun

AU - Sawada, Kei

AU - Takano, H.

AU - Kohmura, Yoshiki

AU - Ishikawa, Tetsuya

AU - Lim, Jae Hong

AU - Je, Jung Ho

AU - Low, Chian Ming

AU - Teo, Alvin

AU - Tok, Eng Soon

AU - Tan, Tin Wee

AU - Ban, Kenneth

AU - Libedinsky, Camilo

AU - Tan, Francis Chee Kuan

AU - Chen, Kuan Peng

AU - Yang, An Cheng

AU - Chuang, Chao Chun

AU - Chen, Nan Yow

AU - Shih, Chi Tin

AU - Lee, Ting Kuo

AU - Yang, De Nian

AU - Lai, Hsu Chao

AU - Shuai, Hong Han

AU - Cheng, Chang Chieh

AU - Ching, Yu Tai

AU - Li, Chia Wei

AU - Charng, Ching Che

AU - Lo, Chung Chuan

AU - Chiang, Ann Shyn

AU - Recur, Benoit

AU - Petibois, Cyril

AU - Cheng, Chia Liang

AU - Chen, Hsiang Hsin

AU - Yang, Shun Min

AU - Hwu, Yeukuang

AU - Rojviriya, Catleya

AU - Rugmai, Supagorn

AU - Rujirawat, Saroj

AU - Margaritondo, Giorgio

PY - 2023/2/9

Y1 - 2023/2/9

N2 - Since 2020, synchrotron radiation facilities in several Asia-Pacific countries have been collaborating in a major project called “SYNAPSE” (Synchrotrons for Neuroscience: an Asia-Pacific Scientific Enterprise). They use x-ray imaging to attack in a coordinated fashion one of the major issues in modern science: the structure of animal and human brains, including neurons and connections. The objective is to develop Google-like maps also including detailed structural and functional information for selected regions of interest. The sheer mass of data needed for the objective poses huge problems for the acquisition, processing, storage and use of images. In order to complete the task within a reasonable time, the key element of the SYNAPSE strategy is the parallel and coordinated work of several facilities on the same specimens. This article reviews different aspects of the enterprise, including the foundations of synchrotron radiation, coherence and of its role in advanced imaging, electron accelerators, x-ray optics and detectors. This will provide the foundation for an extensive presentation of the different components of SYNAPSE, with an overview of results already obtained within the consortium.

AB - Since 2020, synchrotron radiation facilities in several Asia-Pacific countries have been collaborating in a major project called “SYNAPSE” (Synchrotrons for Neuroscience: an Asia-Pacific Scientific Enterprise). They use x-ray imaging to attack in a coordinated fashion one of the major issues in modern science: the structure of animal and human brains, including neurons and connections. The objective is to develop Google-like maps also including detailed structural and functional information for selected regions of interest. The sheer mass of data needed for the objective poses huge problems for the acquisition, processing, storage and use of images. In order to complete the task within a reasonable time, the key element of the SYNAPSE strategy is the parallel and coordinated work of several facilities on the same specimens. This article reviews different aspects of the enterprise, including the foundations of synchrotron radiation, coherence and of its role in advanced imaging, electron accelerators, x-ray optics and detectors. This will provide the foundation for an extensive presentation of the different components of SYNAPSE, with an overview of results already obtained within the consortium.

KW - Brain mapping

KW - Phase contrast

KW - Radiology

KW - Supercomputing

KW - Synchrotron

KW - X-rays

UR - http://www.scopus.com/inward/record.url?scp=85144091013&partnerID=8YFLogxK

U2 - 10.1016/j.physrep.2022.11.003

DO - 10.1016/j.physrep.2022.11.003

M3 - Review article

AN - SCOPUS:85144091013

SN - 0370-1573

VL - 999

SP - 1

EP - 60

JO - Physics Reports

JF - Physics Reports

ER -

SYNAPSE: An international roadmap to large brain imaging

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this