Surface enhanced FTIR spectroscopy on membranes

Ch Kuhne, G. Steiner, W. B. Fischer, R. Salzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The infrared absorption of molecules in the vicinity of small metal clusters is enhanced due to an electric field around the clusters. This phenomenon is known as surface enhanced IR absorption (SEIRA). The potential of SEIRA consists in the investigation of thin layers and of membranes. SEIRA was used to detect small and specific changes in the structure of biomembranes applying two configurations: underlay er and overlay er. In the underlayer configuraiton, IR transparent Ge crystals were coated with Ag clusters before vesicles were adsorbed. In the overlayer configuration, the vesicles were first absorbed on neat Ge crystals before a layer of Ag clusters was condensed on top. An intensity increase in the SEIRA spectra was observed for both configurations compared to FTIR spectra without Ag clusters.

Original languageEnglish
Pages (from-to)750-754
Number of pages5
JournalAnalytical and Bioanalytical Chemistry
Issue number7-8
StatePublished - 1998


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