Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging

Jia Pu Syu, Waradee Buddhakosai, Shih Jen Chen, Chang Chih Ke, Shih Hwa Chiou, Wen Chuan Kuo

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


This study proposed an ultrahigh-resolution multi-contrast optical coherence tomography system integrated with fundus photography for in vivo retinal imaging of rodents. A supercontinuum light source was used in the system, providing an axial resolution of less than 3 µm within 1.8 mm (in the tissue). Three types of tissue contrast based on backscattered intensity, phase retardation, and microvasculature at a capillary level can be simultaneously obtained using the proposed system. Pigmented Long-Evans, non-pigmented (albino) Sprague Dawley, and Royal College of Surgeons rats were imaged and compared. In vivo imaging results were validated with histology.

Original languageEnglish
Article number#346018
Pages (from-to)6132-6144
Number of pages13
JournalBiomedical Optics Express
Issue number12
StatePublished - 1 Dec 2018


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