Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging

Jia Pu Syu; Waradee Buddhakosai; Shih Jen Chen; Chang Chih Ke; Shih Hwa Chiou; Wen Chuan Kuo

doi:10.1364/BOE.9.006132

Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging

Jia Pu Syu, Waradee Buddhakosai, Shih Jen Chen, Chang Chih Ke, Shih Hwa Chiou, Wen Chuan Kuo

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

This study proposed an ultrahigh-resolution multi-contrast optical coherence tomography system integrated with fundus photography for in vivo retinal imaging of rodents. A supercontinuum light source was used in the system, providing an axial resolution of less than 3 µm within 1.8 mm (in the tissue). Three types of tissue contrast based on backscattered intensity, phase retardation, and microvasculature at a capillary level can be simultaneously obtained using the proposed system. Pigmented Long-Evans, non-pigmented (albino) Sprague Dawley, and Royal College of Surgeons rats were imaged and compared. In vivo imaging results were validated with histology.

Original language	English
Article number	#346018
Pages (from-to)	6132-6144
Number of pages	13
Journal	Biomedical Optics Express
Volume	9
Issue number	12
DOIs	https://doi.org/10.1364/BOE.9.006132
State	Published - 1 Dec 2018

Access to Document

10.1364/BOE.9.006132

Cite this

@article{f3811b7e7cb84eefb939e5a83a528ce8,

title = "Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging",

abstract = "This study proposed an ultrahigh-resolution multi-contrast optical coherence tomography system integrated with fundus photography for in vivo retinal imaging of rodents. A supercontinuum light source was used in the system, providing an axial resolution of less than 3 µm within 1.8 mm (in the tissue). Three types of tissue contrast based on backscattered intensity, phase retardation, and microvasculature at a capillary level can be simultaneously obtained using the proposed system. Pigmented Long-Evans, non-pigmented (albino) Sprague Dawley, and Royal College of Surgeons rats were imaged and compared. In vivo imaging results were validated with histology.",

author = "Syu, {Jia Pu} and Waradee Buddhakosai and Chen, {Shih Jen} and Ke, {Chang Chih} and Chiou, {Shih Hwa} and Kuo, {Wen Chuan}",

note = "Publisher Copyright: {\textcopyright} 2018 Optical Society of America.",

year = "2018",

month = dec,

day = "1",

doi = "10.1364/BOE.9.006132",

language = "English",

volume = "9",

pages = "6132--6144",

journal = "Biomedical Optics Express",

issn = "2156-7085",

publisher = "Optica Publishing Group (formerly OSA)",

number = "12",

}

TY - JOUR

T1 - Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging

AU - Syu, Jia Pu

AU - Buddhakosai, Waradee

AU - Chen, Shih Jen

AU - Ke, Chang Chih

AU - Chiou, Shih Hwa

AU - Kuo, Wen Chuan

PY - 2018/12/1

Y1 - 2018/12/1

N2 - This study proposed an ultrahigh-resolution multi-contrast optical coherence tomography system integrated with fundus photography for in vivo retinal imaging of rodents. A supercontinuum light source was used in the system, providing an axial resolution of less than 3 µm within 1.8 mm (in the tissue). Three types of tissue contrast based on backscattered intensity, phase retardation, and microvasculature at a capillary level can be simultaneously obtained using the proposed system. Pigmented Long-Evans, non-pigmented (albino) Sprague Dawley, and Royal College of Surgeons rats were imaged and compared. In vivo imaging results were validated with histology.

AB - This study proposed an ultrahigh-resolution multi-contrast optical coherence tomography system integrated with fundus photography for in vivo retinal imaging of rodents. A supercontinuum light source was used in the system, providing an axial resolution of less than 3 µm within 1.8 mm (in the tissue). Three types of tissue contrast based on backscattered intensity, phase retardation, and microvasculature at a capillary level can be simultaneously obtained using the proposed system. Pigmented Long-Evans, non-pigmented (albino) Sprague Dawley, and Royal College of Surgeons rats were imaged and compared. In vivo imaging results were validated with histology.

UR - http://www.scopus.com/inward/record.url?scp=85057855668&partnerID=8YFLogxK

U2 - 10.1364/BOE.9.006132

DO - 10.1364/BOE.9.006132

M3 - Article

AN - SCOPUS:85057855668

SN - 2156-7085

VL - 9

SP - 6132

EP - 6144

JO - Biomedical Optics Express

JF - Biomedical Optics Express

IS - 12

M1 - #346018

ER -

Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging

Abstract

Access to Document

Other files and links

Fingerprint

Cite this