Sulfoglycolipids and Related Analogues of Mycobacterium tuberculosis: Chemical Synthesis and Immunological Studies

Cheng Hsin Chiu, Janet Jia Yin Tan, Soumik Mondal, Chun Hung Lin, Kwok Kong Tony Mong*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Mycobacterium tuberculosis (Mtb) causes tuberculosis as one major threat to human health, which has been deteriorated owing to the emerging multidrug resistance. Mtb contains a complex lipophilic cell wall structure that is important for bacterial persistence. Among the lipid components, sulfoglycolipids (SGLs), known to induce immune cell responses, are composed of a trehalose core attached with a conserved sulfate group and 1–4 fatty acyl chains in an asymmetric pattern. At least one of these acyl chains is polymethylated with 3–12 methyl branches. Although Mtb SGL can be isolated from bacterial culture, resulting SGL is still a homologous mixture, impeding accurate research studies. This up-to-date review covers the chemical synthesis and immunological studies of Mtb SGLs and structural analogues, with an emphasis on the development of new glycosylation methods and the asymmetric synthesis of polymethylated scaffolds. Both are critical to advance further research on biological functions of these complicated SGLs.

Original languageEnglish
JournalChemMedChem
DOIs
StateAccepted/In press - 2023

Keywords

  • 1,1′-Glycosylation
  • Desymmetrization
  • Mycobacterium tuberculosis
  • Sulfoglycolipids
  • Trehaloses

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