Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32

M. W. Lin; D. Curtis; N. Williams; M. Arranz; S. Nanko; D. Collier; P. McGuffin; R. Murray; M. Owen; M. Gill; J. Powell

doi:10.1097/00041444-199505030-00004

Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32

M. W. Lin^*, D. Curtis, N. Williams, M. Arranz, S. Nanko, D. Collier, P. McGuffin, R. Murray, M. Owen, M. Gill, J. Powell

^*Corresponding author for this work

Institute of Public Health

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under heterogeneity with markers on chromosome 13. A lod2 score of 1.61 for marker D13S144 was obtained at 0 = 0 and ॅ of 0.5 and nearby markers also produced positive values.

Original language	English
Pages (from-to)	117-126
Number of pages	10
Journal	Psychiatric Genetics
Volume	5
Issue number	3
DOIs	https://doi.org/10.1097/00041444-199505030-00004
State	Published - 1995

Keywords

Chromosome 13
Heterogeneity
Linkage analysis
Schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00041444-199505030-00004

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title = "Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32",

abstract = "Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under heterogeneity with markers on chromosome 13. A lod2 score of 1.61 for marker D13S144 was obtained at 0 = 0 and ॅ of 0.5 and nearby markers also produced positive values.",

keywords = "Chromosome 13, Heterogeneity, Linkage analysis, Schizophrenia",

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T1 - Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32

AU - Lin, M. W.

AU - Curtis, D.

AU - Williams, N.

AU - Arranz, M.

AU - Nanko, S.

AU - Collier, D.

AU - McGuffin, P.

AU - Murray, R.

AU - Owen, M.

AU - Gill, M.

AU - Powell, J.

PY - 1995

Y1 - 1995

N2 - Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under heterogeneity with markers on chromosome 13. A lod2 score of 1.61 for marker D13S144 was obtained at 0 = 0 and ॅ of 0.5 and nearby markers also produced positive values.

AB - Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under heterogeneity with markers on chromosome 13. A lod2 score of 1.61 for marker D13S144 was obtained at 0 = 0 and ॅ of 0.5 and nearby markers also produced positive values.

KW - Chromosome 13

KW - Heterogeneity

KW - Linkage analysis

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=0029565202&partnerID=8YFLogxK

U2 - 10.1097/00041444-199505030-00004

DO - 10.1097/00041444-199505030-00004

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AN - SCOPUS:0029565202

SN - 0955-8829

VL - 5

SP - 117

EP - 126

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 3

ER -

Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32

Abstract

Keywords

UN SDGs

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