Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13-14 in Taiwanese families

Chih Min Liu, Hai Gwo Hwu*, Ming Wei Lin, Wen Chen Ou-Yang, Sandy F.C. Lee, Cathy S.J. Fann, Su Hsien Wong, Shu Hua Hsieh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

In order to evaluate the linkage of schizophrenia to loci at chromosome 15q, we genotyped six microsatellite markers at chromosome 15q11-14 in 52 Taiwanese schizophrenic families. Two phenotype models (narrow: DSM-IV schizophrenia only; and broad: including schizophrenia, schizoaffective, and other nonaffective psychotic disorders) were used to define the disease phenotype. Maximum nonparametric linkage scores (NPL scores) of 3.33 (P = 0.0003) and 2.96 (P = 0.0008) were obtained at the marker D15S976 under broad and narrow models, respectively. Positive linkage results were also observed at the marker D15S1360, previously reported to have significant linkage to a neurophysiological deficit of schizophrenia, with NPL scores of 2.71 (P = 0.003) and 2.78 (P = 0.002) under broad and narrow models, respectively. The results provide suggestive linkage evidence of schizophrenia to loci at chromosome 15q13-14 in an ethnically distinct Taiwanese sample.

Original languageEnglish
Pages (from-to)658-661
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume105
Issue number8
DOIs
StatePublished - 8 Dec 2001

Keywords

  • Chromosome 15q
  • Linkage
  • Schizophrenia

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