Subcortical hyperexcitability in migraineurs: A high-frequency oscillation study

Kuan Lin Lai, Kwong Kum Liao, Jong Ling Fuh, Shuu Jiun Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: An abnormal central nervous system excitability level was found in patients with migraine. Whether it is hyper-or hypo-excitable is still debated. This study aimed to compare the somatosensory high-frequency oscillations (HFOs), which reflected subcortical excitability (early phase) and intracortical inhibition (late phase), between patients with migraine and control subjects. Methods: HFOs were recorded from C3'-Fz, using a 500-1000 Hz frequency filter after stimulation at right median nerves at the wrists, and divided into early and late phases based on the N20 peak. Fifty-nine untreated patients (n=24 during ictal period; n=35, interictal) and 22 controls finished the study. Results: In early HFOs, patients both during ictal and interictal periods had higher maximal amplitudes (p =0.039) and area-under-curve (p =0.029) than those of the controls. Regarding the late HFOs, there were no significant differences among these groups. Conclusion: Our study suggests a hyper-excitable state in the subcortical regions in patients with migraine both during interictal and ictal periods.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalCanadian Journal of Neurological Sciences
Issue number2
StatePublished - 1 Mar 2011


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