Stimulus driver for epilepsy seizure suppression with adaptive loading impedance

Ming-Dou Ker*, Chun Yu Lin, Wei Ling Chen

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations


    A stimulus driver circuit for a micro-stimulator used in an implantable device is presented in this paper. For epileptic seizure control, the target of the driver was to output 30 νA stimulus currents when the electrode impedance varied between 20 and 200 kΩ. The driver, which consisted of the output stage, control block and adaptor, was integrated in a single chip. The averaged power consumption of the stimulus driver was 0.24-0.56 mW at 800 Hz stimulation rate. Fabricated in a 0.35 νm 3.3 V/24 V CMOS process and applied to a closed-loop epileptic seizure monitoring and controlling system, the proposed design has been successfully verified in the experimental results of Long-Evans rats with epileptic seizures.

    Original languageEnglish
    Article number066008
    JournalJournal of Neural Engineering
    Issue number6
    StatePublished - Dec 2011


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