State-of-the-art of ultrasound-triggered drug delivery from ultrasound-responsive drug carriers

Ching Hsiang Fan, Yi Ju Ho, Chia Wei Lin, Nan Wu, Pei Hua Chiang, Chih Kuang Yeh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Introduction: Delivering sufficient therapeutics at the target site without off-target effects is a major goal of drug delivery technology innovation. Among the established methods, ultrasound (US) with US-responsible carriers holds great promise and demonstrates on-demand delivery of a variety of functional substances with spatial precision of several millimeters in deep-seated tissues in animal models and humans. These properties have motivated several explorations of US with US responsible-responsible carriers as a modality for neuromodulation and the treatment of various diseases, such as stroke and cancer. Areas covered: We briefly discuss three specific mechanisms that enhance in vivo drug delivery via US with US-responsible carriers: 1) permeabilizing cellular membrane, 2) increasing the permeability of vessels, and 3) promoting cellular endocytotic uptake. We then reviewed the state-of-the-art materials for US-triggered drug delivery, including conventional US contrast agents, and nanocarrier formulations, such as inorganic nanoparticles and gas vesicles. Expert opinion: In this article, we summarized recent progress for each of US-responsible drug carrier, focusing on the routes of enhancing delivery and applications. The mechanisms of interaction between US-responsible carriers and US waves, such as cavitation, streaming, hyperthermia, and ROS, as well as how those interactions can improve drug release and cell/tissue uptake.

Original languageEnglish
Pages (from-to)997-1009
Number of pages13
JournalExpert Opinion on Drug Delivery
Volume19
Issue number8
DOIs
StatePublished - 2022

Keywords

  • droplet
  • drug delivery
  • microbubble
  • nanoparticle
  • Ultrasound
  • ultrasound-responsive carrier

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