Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas

Ming Han Tsai; Ana Raykova; Olaf Klinke; Katharina Bernhardt; Kathrin Gärtner; Carol S. Leung; Karsten Geletneky; Serkan Sertel; Christian Münz; Regina Feederle; Henri Jacques Delecluse

doi:10.1016/j.celrep.2013.09.012

Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas

Ming Han Tsai, Ana Raykova, Olaf Klinke, Katharina Bernhardt, Kathrin Gärtner, Carol S. Leung, Karsten Geletneky, Serkan Sertel, Christian Münz, Regina Feederle^*, Henri Jacques Delecluse

^*Corresponding author for this work

Institute of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

181 Scopus citations

Abstract

The Epstein-Barr virus (EBV) is found in a variety of tumors whose incidence greatly varies around the world. A poorly explored hypothesis is that particular EBV strains account for this phenomenon. We report that M81, a virus isolated from a Chinese patient with nasopharyngeal carcinoma (NPC), shows remarkable similarity to other NPC viruses but is divergent from all other known strains. M81 exhibited a reversed tropism relative to common strains with a reduced ability to infect B cells and a high propensity to infect epithelial cells, which is in agreement with its isolation from carcinomas. M81 spontaneously replicated in B cells invitro and invivo at unusually high levels, in line with the enhanced viral replication observed in NPC patients. Spontaneous replication and epitheliotropism could be partly ascribed to polymorphisms within viral proteins. We suggest considering M81 and its closely related isolates as an EBV subtype with enhanced pathogenic potential

Original language	English
Pages (from-to)	458-470
Number of pages	13
Journal	Cell Reports
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2013.09.012
State	Published - 2013

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title = "Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas",

abstract = "The Epstein-Barr virus (EBV) is found in a variety of tumors whose incidence greatly varies around the world. A poorly explored hypothesis is that particular EBV strains account for this phenomenon. We report that M81, a virus isolated from a Chinese patient with nasopharyngeal carcinoma (NPC), shows remarkable similarity to other NPC viruses but is divergent from all other known strains. M81 exhibited a reversed tropism relative to common strains with a reduced ability to infect B cells and a high propensity to infect epithelial cells, which is in agreement with its isolation from carcinomas. M81 spontaneously replicated in B cells invitro and invivo at unusually high levels, in line with the enhanced viral replication observed in NPC patients. Spontaneous replication and epitheliotropism could be partly ascribed to polymorphisms within viral proteins. We suggest considering M81 and its closely related isolates as an EBV subtype with enhanced pathogenic potential",

author = "Tsai, {Ming Han} and Ana Raykova and Olaf Klinke and Katharina Bernhardt and Kathrin G{\"a}rtner and Leung, {Carol S.} and Karsten Geletneky and Serkan Sertel and Christian M{\"u}nz and Regina Feederle and Delecluse, {Henri Jacques}",

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T1 - Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas

AU - Tsai, Ming Han

AU - Raykova, Ana

AU - Klinke, Olaf

AU - Bernhardt, Katharina

AU - Gärtner, Kathrin

AU - Leung, Carol S.

AU - Geletneky, Karsten

AU - Sertel, Serkan

AU - Münz, Christian

AU - Feederle, Regina

AU - Delecluse, Henri Jacques

PY - 2013

Y1 - 2013

N2 - The Epstein-Barr virus (EBV) is found in a variety of tumors whose incidence greatly varies around the world. A poorly explored hypothesis is that particular EBV strains account for this phenomenon. We report that M81, a virus isolated from a Chinese patient with nasopharyngeal carcinoma (NPC), shows remarkable similarity to other NPC viruses but is divergent from all other known strains. M81 exhibited a reversed tropism relative to common strains with a reduced ability to infect B cells and a high propensity to infect epithelial cells, which is in agreement with its isolation from carcinomas. M81 spontaneously replicated in B cells invitro and invivo at unusually high levels, in line with the enhanced viral replication observed in NPC patients. Spontaneous replication and epitheliotropism could be partly ascribed to polymorphisms within viral proteins. We suggest considering M81 and its closely related isolates as an EBV subtype with enhanced pathogenic potential

AB - The Epstein-Barr virus (EBV) is found in a variety of tumors whose incidence greatly varies around the world. A poorly explored hypothesis is that particular EBV strains account for this phenomenon. We report that M81, a virus isolated from a Chinese patient with nasopharyngeal carcinoma (NPC), shows remarkable similarity to other NPC viruses but is divergent from all other known strains. M81 exhibited a reversed tropism relative to common strains with a reduced ability to infect B cells and a high propensity to infect epithelial cells, which is in agreement with its isolation from carcinomas. M81 spontaneously replicated in B cells invitro and invivo at unusually high levels, in line with the enhanced viral replication observed in NPC patients. Spontaneous replication and epitheliotropism could be partly ascribed to polymorphisms within viral proteins. We suggest considering M81 and its closely related isolates as an EBV subtype with enhanced pathogenic potential

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ER -

Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas

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