Spontaneous intracranial hypotension complicated by malignancyinduced disseminated intravascular coagulation: A case report

Hung Yi Wu; Shu Shya Hseu; Shih Pin Chen; Jiing Feng Lirng; Yen Feng Wang; Shuu Jiun Wang; Jong Ling Fuh

Spontaneous intracranial hypotension complicated by malignancyinduced disseminated intravascular coagulation: A case report

Hung Yi Wu, Shu Shya Hseu, Shih Pin Chen, Jiing Feng Lirng, Yen Feng Wang, Shuu Jiun Wang, Jong Ling Fuh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Purpose: Spontaneous intracranial hypotension (SIH) is a rare type of headache. The association of SIH with malignancy and disseminated intravascular coagulation (DIC) has not previously been reported. Case Report: A 60-year-old woman had orthostatic headache for more than one month before admission. MRI of brain showed diffuse pachymeningeal enhancement with bilateral subdural hematoma. MR myelography revealed epidural fluid collection and possible CSF leakage at the level of C5 to C6. DIC due to carcinoma of unknown origin was found based on evidence of malignant pleural effusion and multiple bone metastases. After correction of coagulopathy, the patient received an epidural blood patch. Unfortunately, follow-up brain MRI showed disease progression. The patient died of acute respiratory failure four weeks after admission. Conclusion: This is the first case report of an association between SIH and DIC due to malignancy. Further case studies are needed to provide further support of this association.

Original language	English
Pages (from-to)	95-98
Number of pages	4
Journal	Acta Neurologica Taiwanica
Volume	25
Issue number	3
State	Published - 15 Sep 2016

Keywords

Disseminated intravascular coagulation
Spontaneous intracranial hypotension

Cite this

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title = "Spontaneous intracranial hypotension complicated by malignancyinduced disseminated intravascular coagulation: A case report",

abstract = "Purpose: Spontaneous intracranial hypotension (SIH) is a rare type of headache. The association of SIH with malignancy and disseminated intravascular coagulation (DIC) has not previously been reported. Case Report: A 60-year-old woman had orthostatic headache for more than one month before admission. MRI of brain showed diffuse pachymeningeal enhancement with bilateral subdural hematoma. MR myelography revealed epidural fluid collection and possible CSF leakage at the level of C5 to C6. DIC due to carcinoma of unknown origin was found based on evidence of malignant pleural effusion and multiple bone metastases. After correction of coagulopathy, the patient received an epidural blood patch. Unfortunately, follow-up brain MRI showed disease progression. The patient died of acute respiratory failure four weeks after admission. Conclusion: This is the first case report of an association between SIH and DIC due to malignancy. Further case studies are needed to provide further support of this association.",

keywords = "Disseminated intravascular coagulation, Spontaneous intracranial hypotension",

author = "Wu, {Hung Yi} and Hseu, {Shu Shya} and Chen, {Shih Pin} and Lirng, {Jiing Feng} and Wang, {Yen Feng} and Wang, {Shuu Jiun} and Fuh, {Jong Ling}",

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language = "English",

volume = "25",

pages = "95--98",

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publisher = "Taiwan Neurological Society",

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T1 - Spontaneous intracranial hypotension complicated by malignancyinduced disseminated intravascular coagulation

T2 - A case report

AU - Wu, Hung Yi

AU - Hseu, Shu Shya

AU - Chen, Shih Pin

AU - Lirng, Jiing Feng

AU - Wang, Yen Feng

AU - Wang, Shuu Jiun

AU - Fuh, Jong Ling

PY - 2016/9/15

Y1 - 2016/9/15

N2 - Purpose: Spontaneous intracranial hypotension (SIH) is a rare type of headache. The association of SIH with malignancy and disseminated intravascular coagulation (DIC) has not previously been reported. Case Report: A 60-year-old woman had orthostatic headache for more than one month before admission. MRI of brain showed diffuse pachymeningeal enhancement with bilateral subdural hematoma. MR myelography revealed epidural fluid collection and possible CSF leakage at the level of C5 to C6. DIC due to carcinoma of unknown origin was found based on evidence of malignant pleural effusion and multiple bone metastases. After correction of coagulopathy, the patient received an epidural blood patch. Unfortunately, follow-up brain MRI showed disease progression. The patient died of acute respiratory failure four weeks after admission. Conclusion: This is the first case report of an association between SIH and DIC due to malignancy. Further case studies are needed to provide further support of this association.

AB - Purpose: Spontaneous intracranial hypotension (SIH) is a rare type of headache. The association of SIH with malignancy and disseminated intravascular coagulation (DIC) has not previously been reported. Case Report: A 60-year-old woman had orthostatic headache for more than one month before admission. MRI of brain showed diffuse pachymeningeal enhancement with bilateral subdural hematoma. MR myelography revealed epidural fluid collection and possible CSF leakage at the level of C5 to C6. DIC due to carcinoma of unknown origin was found based on evidence of malignant pleural effusion and multiple bone metastases. After correction of coagulopathy, the patient received an epidural blood patch. Unfortunately, follow-up brain MRI showed disease progression. The patient died of acute respiratory failure four weeks after admission. Conclusion: This is the first case report of an association between SIH and DIC due to malignancy. Further case studies are needed to provide further support of this association.

KW - Disseminated intravascular coagulation

KW - Spontaneous intracranial hypotension

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M3 - Article

C2 - 27854087

AN - SCOPUS:84994756511

SN - 1028-768X

VL - 25

SP - 95

EP - 98

JO - Acta Neurologica Taiwanica

JF - Acta Neurologica Taiwanica

IS - 3

ER -

Spontaneous intracranial hypotension complicated by malignancyinduced disseminated intravascular coagulation: A case report

Abstract

Keywords

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