Abstract
Derivatives of indolo[2,1-b]quinazolinone containing aminoalkylamino side chains were synthesized as specific DNA triplex stabilizing agents. The aminoalkylamino side chains are essential for triplex stabilization. The position-8 fluorine atom or a methyl group to the nitrogen adjacent to the planar core can enhance triplex stability by 6 °C and the effect is additive. Conformational analysis reveals that the orientation of the side chain underlies the ability of this compound to stabilize a DNA triplex.
Original language | English |
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Pages (from-to) | 1769-1772 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 17 |
Issue number | 6 |
DOIs | |
State | Published - 15 Mar 2007 |
Keywords
- DNA triplex
- Indolo[2,1-b]quinazolin-6,12-dione
- Thermal denaturation
- Triplex stabilizing agents
- Tryptanthrin