SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation

Rai Hua Lai, Ya Wen Hsiao, Mei Jung Wang, Huan Yu Lin, Chew Wun Wu, Chin Wen Chi, Anna Fen Yau Li, Yuh Shan Jou, Jeou Yuan Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Members of the suppressor of cytokine-induced signaling (SOCS) family are negative regulators of cytokine signaling pathways. By mRNA differential display, we showed that SOCS6 was frequently down-regulated in gastric cancer (GC). Our data showed that allelic loss and promoter hypermethylation may account for the major mechanisms leading to SOCS6 inactivation. Ectopic expression of SOCS6 suppressed cell growth and colony formation, in part through eliciting intrinsic apoptotic pathway, accompanied with decreased mitochondrial membrane potential. Taken together, this study provides molecular and functional data supporting the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis.

Original languageEnglish
Pages (from-to)75-85
Number of pages11
JournalCancer Letters
Issue number1
StatePublished - 1 Feb 2010


  • Apoptosis
  • Gastric cancer
  • Growth suppression
  • Loss of heterozygosity
  • Promoter hypermethylation
  • SOCS6


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