Abstract
Members of the suppressor of cytokine-induced signaling (SOCS) family are negative regulators of cytokine signaling pathways. By mRNA differential display, we showed that SOCS6 was frequently down-regulated in gastric cancer (GC). Our data showed that allelic loss and promoter hypermethylation may account for the major mechanisms leading to SOCS6 inactivation. Ectopic expression of SOCS6 suppressed cell growth and colony formation, in part through eliciting intrinsic apoptotic pathway, accompanied with decreased mitochondrial membrane potential. Taken together, this study provides molecular and functional data supporting the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis.
Original language | English |
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Pages (from-to) | 75-85 |
Number of pages | 11 |
Journal | Cancer Letters |
Volume | 288 |
Issue number | 1 |
DOIs | |
State | Published - 1 Feb 2010 |
Keywords
- Apoptosis
- Gastric cancer
- Growth suppression
- Loss of heterozygosity
- Promoter hypermethylation
- SOCS6