SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation

Rai Hua Lai; Ya Wen Hsiao; Mei Jung Wang; Huan Yu Lin; Chew Wun Wu; Chin Wen Chi; Anna Fen Yau Li; Yuh Shan Jou; Jeou Yuan Chen

doi:10.1016/j.canlet.2009.06.025

SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation

Rai Hua Lai, Ya Wen Hsiao, Mei Jung Wang, Huan Yu Lin, Chew Wun Wu, Chin Wen Chi, Anna Fen Yau Li, Yuh Shan Jou, Jeou Yuan Chen^*

^*Corresponding author for this work

Department of Pathology

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Members of the suppressor of cytokine-induced signaling (SOCS) family are negative regulators of cytokine signaling pathways. By mRNA differential display, we showed that SOCS6 was frequently down-regulated in gastric cancer (GC). Our data showed that allelic loss and promoter hypermethylation may account for the major mechanisms leading to SOCS6 inactivation. Ectopic expression of SOCS6 suppressed cell growth and colony formation, in part through eliciting intrinsic apoptotic pathway, accompanied with decreased mitochondrial membrane potential. Taken together, this study provides molecular and functional data supporting the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis.

Original language	English
Pages (from-to)	75-85
Number of pages	11
Journal	Cancer Letters
Volume	288
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2009.06.025
State	Published - 1 Feb 2010

Keywords

Apoptosis
Gastric cancer
Growth suppression
Loss of heterozygosity
Promoter hypermethylation
SOCS6

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2009.06.025

Cite this

@article{b82757fc471b49c89a249f599679b375,

title = "SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation",

abstract = "Members of the suppressor of cytokine-induced signaling (SOCS) family are negative regulators of cytokine signaling pathways. By mRNA differential display, we showed that SOCS6 was frequently down-regulated in gastric cancer (GC). Our data showed that allelic loss and promoter hypermethylation may account for the major mechanisms leading to SOCS6 inactivation. Ectopic expression of SOCS6 suppressed cell growth and colony formation, in part through eliciting intrinsic apoptotic pathway, accompanied with decreased mitochondrial membrane potential. Taken together, this study provides molecular and functional data supporting the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis.",

keywords = "Apoptosis, Gastric cancer, Growth suppression, Loss of heterozygosity, Promoter hypermethylation, SOCS6",

author = "Lai, {Rai Hua} and Hsiao, {Ya Wen} and Wang, {Mei Jung} and Lin, {Huan Yu} and Wu, {Chew Wun} and Chi, {Chin Wen} and Li, {Anna Fen Yau} and Jou, {Yuh Shan} and Chen, {Jeou Yuan}",

note = "Funding Information: This work was supported, in part, by National Science Council Grant AS94M009-3 (J.Y.C.).",

year = "2010",

month = feb,

day = "1",

doi = "10.1016/j.canlet.2009.06.025",

language = "English",

volume = "288",

pages = "75--85",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

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TY - JOUR

T1 - SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation

AU - Lai, Rai Hua

AU - Hsiao, Ya Wen

AU - Wang, Mei Jung

AU - Lin, Huan Yu

AU - Wu, Chew Wun

AU - Chi, Chin Wen

AU - Li, Anna Fen Yau

AU - Jou, Yuh Shan

AU - Chen, Jeou Yuan

N1 - Funding Information: This work was supported, in part, by National Science Council Grant AS94M009-3 (J.Y.C.).

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Members of the suppressor of cytokine-induced signaling (SOCS) family are negative regulators of cytokine signaling pathways. By mRNA differential display, we showed that SOCS6 was frequently down-regulated in gastric cancer (GC). Our data showed that allelic loss and promoter hypermethylation may account for the major mechanisms leading to SOCS6 inactivation. Ectopic expression of SOCS6 suppressed cell growth and colony formation, in part through eliciting intrinsic apoptotic pathway, accompanied with decreased mitochondrial membrane potential. Taken together, this study provides molecular and functional data supporting the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis.

AB - Members of the suppressor of cytokine-induced signaling (SOCS) family are negative regulators of cytokine signaling pathways. By mRNA differential display, we showed that SOCS6 was frequently down-regulated in gastric cancer (GC). Our data showed that allelic loss and promoter hypermethylation may account for the major mechanisms leading to SOCS6 inactivation. Ectopic expression of SOCS6 suppressed cell growth and colony formation, in part through eliciting intrinsic apoptotic pathway, accompanied with decreased mitochondrial membrane potential. Taken together, this study provides molecular and functional data supporting the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis.

KW - Apoptosis

KW - Gastric cancer

KW - Growth suppression

KW - Loss of heterozygosity

KW - Promoter hypermethylation

KW - SOCS6

UR - http://www.scopus.com/inward/record.url?scp=73649123906&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2009.06.025

DO - 10.1016/j.canlet.2009.06.025

M3 - Article

C2 - 19646809

AN - SCOPUS:73649123906

SN - 0304-3835

VL - 288

SP - 75

EP - 85

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation

Abstract

Keywords

UN SDGs

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