Social perception of young adults prolongs the lifespan of aged Drosophila

Li Chun Cho, Chih Chieh Yu, Chih Fei Kao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Lifespan is modulated at distinct levels by multiple factors, including genetic backgrounds, the environment, behavior traits, metabolic status, and more interestingly, sensory perceptions. However, the effects of social perception between individuals living in the same space remain less clear. Here, we used the Drosophila model to study the influences of social perception on the lifespan of aged fruit flies. We found the lifespan of aged Drosophila is markedly prolonged after being co-housed with young adults of the same gender. Moreover, the changes of lifespan were affected by several experimental contexts: (1) the ratios of aged and young adults co-housed, (2) the chronological ages of two populations, and (3) the integrity of sensory modalities. Together, we hypothesize the chemical/physical stimuli derived from the interacting young adults are capable of interfering with the physiology and behavior of aged flies, ultimately leading to the alteration of lifespan.

Original languageEnglish
Article number21
Journalnpj Aging and Mechanisms of Disease
Issue number1
StatePublished - Dec 2021


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