Sleep disturbance correlates with white matter hyperintensity in patients with subcortical ischemic vascular dementia

Chun Yu Cheng, Chia Fen Tsai, Shuu Jiun Wang, Chung Yao Hsu, Jong Ling Fuh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Background: Subcortical ischemic vascular dementia (SIVD) caused by small-artery disease, and hypoperfusion is a major cause of vascular cognitive impairment. Little is known about the relationship between sleep disturbance and white matter hyperintensity (WMH). We investigated the association between sleep disturbance and WMH, measured by magnetic resonance imaging (MRI), in patients with SIVD. Methods: Patients with SIVD recruited from our outpatient clinic completed the Sleep Disturbance Symptom Questionnaire (SDSQ) and Geriatric Depression Scale-short form (GDS-S) and underwent brain MRI. Total SDSQ scores were calculated by summing frequency ratings of the instruments 20 items. We graded WMH on brain MR images using a visual rating scale ranging from 0 (barely detectable) to 9 (extensive changes). Results: We enrolled 72 patients (31 men, 41 women; mean age, 75.9 ± 7.9 years) with SIVD. The SDSQ scores were positively correlated with WMH grading (r = .337, P = .001) and tended to be associated with higher GDS-S scores (r = .268, P = .022). Patients with diabetes mellitus tended to display higher mean WMH severity than those without diabetes (4.2 vs 3.3, P = .022). After controlling for confounding factors, the multivariate regression model showed that WMH severity was significantly associated with sleep disturbance (P = .002). Conclusions: This study showed that manifestations of sleep disturbance were significantly associated with WMH severity, with most symptoms related to daytime hypersomnolence. Disruption of the frontal-subcortical neuronal circuit might play a role in sleep disturbance in patients with SIVD.

Original languageEnglish
Pages (from-to)158-164
Number of pages7
JournalJournal of Geriatric Psychiatry and Neurology
Issue number3
StatePublished - Sep 2013


  • frontal-subcortical neuronal circuit
  • sleep disturbance
  • Sleep Disturbance Symptom Questionnaire
  • subcortical ischemic vascular dementia
  • white matter hyperintensity


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