Skin Metabolomics

Decibel P. Elpa; Hsien Yi Chiu; Shu Pao Wu; Pawel L. Urban

doi:10.1016/j.tem.2020.11.009

Skin Metabolomics

Decibel P. Elpa, Hsien Yi Chiu^*, Shu Pao Wu, Pawel L. Urban

^*Corresponding author for this work

Department of Applied Chemistry

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

Skin retains numerous low-molecular-weight compounds (metabolites). Some of these compounds fulfill specific physiological roles, while others are by-products of metabolism. The skin surface can be sampled to detect and quantify skin metabolites related to diseases. Miniature probes have been developed to detect selected high-abundance metabolites secreted with sweat. To characterize a broad spectrum of skin metabolites, specimens are collected with one of several available methods, and the processed specimens are analyzed by chromatography, mass spectrometry (MS), or other techniques. Diseases for which skin-related biomarkers have been found include cystic fibrosis (CF), psoriasis, Parkinson's disease (PD), and lung cancer. To increase the clinical significance of skin metabolomics, it is desirable to verify correlations between metabolite levels in skin and other biological tissues/matrices.

Original language	English
Pages (from-to)	66-75
Number of pages	10
Journal	Trends in Endocrinology and Metabolism
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/j.tem.2020.11.009
State	Published - Feb 2021

Keywords

clinical chemistry
metabolomics
skin metabolism
sweat

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2020.11.009

Cite this

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title = "Skin Metabolomics",

abstract = "Skin retains numerous low-molecular-weight compounds (metabolites). Some of these compounds fulfill specific physiological roles, while others are by-products of metabolism. The skin surface can be sampled to detect and quantify skin metabolites related to diseases. Miniature probes have been developed to detect selected high-abundance metabolites secreted with sweat. To characterize a broad spectrum of skin metabolites, specimens are collected with one of several available methods, and the processed specimens are analyzed by chromatography, mass spectrometry (MS), or other techniques. Diseases for which skin-related biomarkers have been found include cystic fibrosis (CF), psoriasis, Parkinson's disease (PD), and lung cancer. To increase the clinical significance of skin metabolomics, it is desirable to verify correlations between metabolite levels in skin and other biological tissues/matrices.",

keywords = "clinical chemistry, metabolomics, skin metabolism, sweat",

author = "Elpa, {Decibel P.} and Chiu, {Hsien Yi} and Wu, {Shu Pao} and Urban, {Pawel L.}",

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doi = "10.1016/j.tem.2020.11.009",

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TY - JOUR

T1 - Skin Metabolomics

AU - Elpa, Decibel P.

AU - Chiu, Hsien Yi

AU - Wu, Shu Pao

AU - Urban, Pawel L.

PY - 2021/2

Y1 - 2021/2

N2 - Skin retains numerous low-molecular-weight compounds (metabolites). Some of these compounds fulfill specific physiological roles, while others are by-products of metabolism. The skin surface can be sampled to detect and quantify skin metabolites related to diseases. Miniature probes have been developed to detect selected high-abundance metabolites secreted with sweat. To characterize a broad spectrum of skin metabolites, specimens are collected with one of several available methods, and the processed specimens are analyzed by chromatography, mass spectrometry (MS), or other techniques. Diseases for which skin-related biomarkers have been found include cystic fibrosis (CF), psoriasis, Parkinson's disease (PD), and lung cancer. To increase the clinical significance of skin metabolomics, it is desirable to verify correlations between metabolite levels in skin and other biological tissues/matrices.

AB - Skin retains numerous low-molecular-weight compounds (metabolites). Some of these compounds fulfill specific physiological roles, while others are by-products of metabolism. The skin surface can be sampled to detect and quantify skin metabolites related to diseases. Miniature probes have been developed to detect selected high-abundance metabolites secreted with sweat. To characterize a broad spectrum of skin metabolites, specimens are collected with one of several available methods, and the processed specimens are analyzed by chromatography, mass spectrometry (MS), or other techniques. Diseases for which skin-related biomarkers have been found include cystic fibrosis (CF), psoriasis, Parkinson's disease (PD), and lung cancer. To increase the clinical significance of skin metabolomics, it is desirable to verify correlations between metabolite levels in skin and other biological tissues/matrices.

KW - clinical chemistry

KW - metabolomics

KW - skin metabolism

KW - sweat

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U2 - 10.1016/j.tem.2020.11.009

DO - 10.1016/j.tem.2020.11.009

M3 - Review article

C2 - 33353809

AN - SCOPUS:85098198368

SN - 1043-2760

VL - 32

SP - 66

EP - 75

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

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ER -

Skin Metabolomics

Abstract

Keywords

UN SDGs

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