Abstract
The synergistic control of the SH2 transition states of hydrogen abstraction by polar and steric effects provides a promising strategy in achieving site-selective C(sp3)-H functionalization under decatungstate anion photocatalysis. By using this photocatalytic approach, the C-H bonds of alkanes, alcohols, ethers, ketones, amides, esters, nitriles, and pyridylalkanes were functionalized site-selectively. In the remarkable case of a 2,4-disubstituted cyclohexanone bearing five methyl, five methylene, and three methine C-H bonds, one methine C-H bond in the isoamyl tether was selectively functionalized.
Original language | English |
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Pages (from-to) | 701-713 |
Number of pages | 13 |
Journal | ACS Catalysis |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - 5 Dec 2017 |
Keywords
- C(sp3)−H functionalization
- alkanes
- carbonyl compounds
- decatungstate anion
- nitriles
- photocatalysis
- polar effects
- steric effects