Sinus Node Dysfunction after Successful Atrial Flutter Ablation during Follow-Up: Clinical Characteristics and Predictors

Guan Yi Li; Fa Po Chung; Tze Fan Chao; Yenn Jiang Lin; Shih Lin Chang; Li Wei Lo; Yu Feng Hu; Ta Chuan Tuan; Jo Nan Liao; Ting Yung Chang; Ling Kuo; Cheng I. Wu; Chih Min Liu; Shin Huei Liu; Wen Han Cheng; Shih Ann Chen

doi:10.3390/jcm11113212

Sinus Node Dysfunction after Successful Atrial Flutter Ablation during Follow-Up: Clinical Characteristics and Predictors

Guan Yi Li, Fa Po Chung^*, Tze Fan Chao, Yenn Jiang Lin, Shih Lin Chang, Li Wei Lo, Yu Feng Hu, Ta Chuan Tuan, Jo Nan Liao, Ting Yung Chang, Ling Kuo, Cheng I. Wu, Chih Min Liu, Shin Huei Liu, Wen Han Cheng, Shih Ann Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Identification of sinus node dysfunction (SND) before termination of persistent AFL by catheter ablation (CA) is challenging. This study aimed to investigate the characteristics and predictors of acute and delayed SND after AFL ablation. We retrospectively enrolled 221 patients undergoing CA of persistent AFL in a tertiary referral center. Patients with SND who required a temporary pacemaker (TPM) after termination of AFL or a permanent pacemaker (PPM) during follow-up were identified. Acute SND requiring a TPM was found in 14 of 221 (6.3%) patients following successful termination of AFL. A total of 10 of the 14 patients (71.4%) recovered from acute SND. An additional 11 (5%) patients presenting with delayed SND required a PPM during follow-up, including 4 patients recovering from acute SND. Of these, 9 of these 11 patients (81.8%) underwent PPM implantation within 1 year after the ablation. In multivariable analysis, female gender and a history of hypothyroidism were associated with the requirement for a TPM following termination of persistent AFL, while older age and a history of hypothyroidism predicted PPM implantation. This study concluded that the majority of patients with acute SND still require a PPM implantation despite the initial improvement. Therefore, it is reasonable to monitor the patients closely for at least one year after AFL ablation.

Original language	English
Article number	3212
Journal	Journal of Clinical Medicine
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/jcm11113212
State	Published - 1 Jun 2022

Keywords

atrial flutter
catheter ablation
permanent pacemaker
sinus node dysfunction
temporary pacemaker

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10.3390/jcm11113212

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Li, G. Y., Chung, F. P., Chao, T. F., Lin, Y. J., Chang, S. L., Lo, L. W., Hu, Y. F., Tuan, T. C., Liao, J. N., Chang, T. Y., Kuo, L., Wu, C. I., Liu, C. M., Liu, S. H., Cheng, W. H., & Chen, S. A. (2022). Sinus Node Dysfunction after Successful Atrial Flutter Ablation during Follow-Up: Clinical Characteristics and Predictors. Journal of Clinical Medicine, 11(11), Article 3212. https://doi.org/10.3390/jcm11113212

@article{e15bdc6a8a6d458b85bc0cd4009b410e,

title = "Sinus Node Dysfunction after Successful Atrial Flutter Ablation during Follow-Up: Clinical Characteristics and Predictors",

abstract = "Identification of sinus node dysfunction (SND) before termination of persistent AFL by catheter ablation (CA) is challenging. This study aimed to investigate the characteristics and predictors of acute and delayed SND after AFL ablation. We retrospectively enrolled 221 patients undergoing CA of persistent AFL in a tertiary referral center. Patients with SND who required a temporary pacemaker (TPM) after termination of AFL or a permanent pacemaker (PPM) during follow-up were identified. Acute SND requiring a TPM was found in 14 of 221 (6.3%) patients following successful termination of AFL. A total of 10 of the 14 patients (71.4%) recovered from acute SND. An additional 11 (5%) patients presenting with delayed SND required a PPM during follow-up, including 4 patients recovering from acute SND. Of these, 9 of these 11 patients (81.8%) underwent PPM implantation within 1 year after the ablation. In multivariable analysis, female gender and a history of hypothyroidism were associated with the requirement for a TPM following termination of persistent AFL, while older age and a history of hypothyroidism predicted PPM implantation. This study concluded that the majority of patients with acute SND still require a PPM implantation despite the initial improvement. Therefore, it is reasonable to monitor the patients closely for at least one year after AFL ablation.",

keywords = "atrial flutter, catheter ablation, permanent pacemaker, sinus node dysfunction, temporary pacemaker",

author = "Li, {Guan Yi} and Chung, {Fa Po} and Chao, {Tze Fan} and Lin, {Yenn Jiang} and Chang, {Shih Lin} and Lo, {Li Wei} and Hu, {Yu Feng} and Tuan, {Ta Chuan} and Liao, {Jo Nan} and Chang, {Ting Yung} and Ling Kuo and Wu, {Cheng I.} and Liu, {Chih Min} and Liu, {Shin Huei} and Cheng, {Wen Han} and Chen, {Shih Ann}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

day = "1",

doi = "10.3390/jcm11113212",

language = "English",

volume = "11",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

publisher = "MDPI AG",

number = "11",

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Li, GY, Chung, FP, Chao, TF, Lin, YJ , Chang, SL , Lo, LW , Hu, YF, Tuan, TC, Liao, JN, Chang, TY, Kuo, L, Wu, CI, Liu, CM, Liu, SH, Cheng, WH & Chen, SA 2022, 'Sinus Node Dysfunction after Successful Atrial Flutter Ablation during Follow-Up: Clinical Characteristics and Predictors', Journal of Clinical Medicine, vol. 11, no. 11, 3212. https://doi.org/10.3390/jcm11113212

TY - JOUR

T1 - Sinus Node Dysfunction after Successful Atrial Flutter Ablation during Follow-Up

T2 - Clinical Characteristics and Predictors

AU - Li, Guan Yi

AU - Chung, Fa Po

AU - Chao, Tze Fan

AU - Lin, Yenn Jiang

AU - Chang, Shih Lin

AU - Lo, Li Wei

AU - Hu, Yu Feng

AU - Tuan, Ta Chuan

AU - Liao, Jo Nan

AU - Chang, Ting Yung

AU - Kuo, Ling

AU - Wu, Cheng I.

AU - Liu, Chih Min

AU - Liu, Shin Huei

AU - Cheng, Wen Han

AU - Chen, Shih Ann

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Identification of sinus node dysfunction (SND) before termination of persistent AFL by catheter ablation (CA) is challenging. This study aimed to investigate the characteristics and predictors of acute and delayed SND after AFL ablation. We retrospectively enrolled 221 patients undergoing CA of persistent AFL in a tertiary referral center. Patients with SND who required a temporary pacemaker (TPM) after termination of AFL or a permanent pacemaker (PPM) during follow-up were identified. Acute SND requiring a TPM was found in 14 of 221 (6.3%) patients following successful termination of AFL. A total of 10 of the 14 patients (71.4%) recovered from acute SND. An additional 11 (5%) patients presenting with delayed SND required a PPM during follow-up, including 4 patients recovering from acute SND. Of these, 9 of these 11 patients (81.8%) underwent PPM implantation within 1 year after the ablation. In multivariable analysis, female gender and a history of hypothyroidism were associated with the requirement for a TPM following termination of persistent AFL, while older age and a history of hypothyroidism predicted PPM implantation. This study concluded that the majority of patients with acute SND still require a PPM implantation despite the initial improvement. Therefore, it is reasonable to monitor the patients closely for at least one year after AFL ablation.

AB - Identification of sinus node dysfunction (SND) before termination of persistent AFL by catheter ablation (CA) is challenging. This study aimed to investigate the characteristics and predictors of acute and delayed SND after AFL ablation. We retrospectively enrolled 221 patients undergoing CA of persistent AFL in a tertiary referral center. Patients with SND who required a temporary pacemaker (TPM) after termination of AFL or a permanent pacemaker (PPM) during follow-up were identified. Acute SND requiring a TPM was found in 14 of 221 (6.3%) patients following successful termination of AFL. A total of 10 of the 14 patients (71.4%) recovered from acute SND. An additional 11 (5%) patients presenting with delayed SND required a PPM during follow-up, including 4 patients recovering from acute SND. Of these, 9 of these 11 patients (81.8%) underwent PPM implantation within 1 year after the ablation. In multivariable analysis, female gender and a history of hypothyroidism were associated with the requirement for a TPM following termination of persistent AFL, while older age and a history of hypothyroidism predicted PPM implantation. This study concluded that the majority of patients with acute SND still require a PPM implantation despite the initial improvement. Therefore, it is reasonable to monitor the patients closely for at least one year after AFL ablation.

KW - atrial flutter

KW - catheter ablation

KW - permanent pacemaker

KW - sinus node dysfunction

KW - temporary pacemaker

UR - http://www.scopus.com/inward/record.url?scp=85131159343&partnerID=8YFLogxK

U2 - 10.3390/jcm11113212

DO - 10.3390/jcm11113212

M3 - Article

AN - SCOPUS:85131159343

SN - 2077-0383

VL - 11

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 11

M1 - 3212

ER -

Sinus Node Dysfunction after Successful Atrial Flutter Ablation during Follow-Up: Clinical Characteristics and Predictors

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Keywords

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