TY - JOUR
T1 - Single versus multi-dose vaccine vials
T2 - An economic computational model
AU - Lee, Bruce Y.
AU - Norman, Bryan A.
AU - Assi, Tina Marie
AU - Chen, Sheng-I
AU - Bailey, Rachel R.
AU - Rajgopal, Jayant
AU - Brown, Shawn T.
AU - Wiringa, Ann E.
AU - Burke, Donald S.
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Single-dose vaccine formats can prevent clinic-level vaccine wastage but may incur higher production, medical waste disposal, and storage costs than multi-dose formats. To help guide vaccine developers, manufacturers, distributors, and purchasers, we developed a computational model to predict the potential economic impact of various single-dose versus multi-dose measles (MEA), hemophilus influenzae type B (Hib), Bacille Calmette-Guérin (BCG), yellow fever (YF), and pentavalent (DTP-HepB-Hib) vaccine formats. Lower patient demand favors fewer dose formats. The mean daily patient arrival thresholds for each vaccine format are as follows: for the MEA vaccine, 2 patients/day (below which the single-dose vial and above which the 10-dose vial are least costly); BCG vaccine, 6 patients/day (below, 10-dose vial; above, 20-dose vial); Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial); YF vaccine, 33 patients/day (below, 5-dose vials; above 50-dose vial); and DTP-HepB-Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial).
AB - Single-dose vaccine formats can prevent clinic-level vaccine wastage but may incur higher production, medical waste disposal, and storage costs than multi-dose formats. To help guide vaccine developers, manufacturers, distributors, and purchasers, we developed a computational model to predict the potential economic impact of various single-dose versus multi-dose measles (MEA), hemophilus influenzae type B (Hib), Bacille Calmette-Guérin (BCG), yellow fever (YF), and pentavalent (DTP-HepB-Hib) vaccine formats. Lower patient demand favors fewer dose formats. The mean daily patient arrival thresholds for each vaccine format are as follows: for the MEA vaccine, 2 patients/day (below which the single-dose vial and above which the 10-dose vial are least costly); BCG vaccine, 6 patients/day (below, 10-dose vial; above, 20-dose vial); Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial); YF vaccine, 33 patients/day (below, 5-dose vials; above 50-dose vial); and DTP-HepB-Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial).
KW - Doses per vial
KW - Economics
KW - Vaccines
UR - http://www.scopus.com/inward/record.url?scp=77954953514&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2010.05.048
DO - 10.1016/j.vaccine.2010.05.048
M3 - Article
C2 - 20566395
AN - SCOPUS:77954953514
SN - 0264-410X
VL - 28
SP - 5292
EP - 5300
JO - Vaccine
JF - Vaccine
IS - 32
ER -
