Simple parameters of synthetic MRI for assessment of bone density in patients with spinal degenerative disease

Hsuan Kan Chang, Tun Wei Hsu, Johnson Ku, Jason Ku, Jau Ching Wu, Jiing Feng Lirng, Shih Ming Hsu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


OBJECTIVE Good bone quality is the key to avoiding osteoporotic fragility fractures and poor outcomes after lumbar instrumentation and fusion surgery. Although dual-energy x-ray absorptiometry (DEXA) screening is the current standard for evaluating osteoporosis, many patients lack DEXA measurements before undergoing lumbar spine surgery. The present study aimed to investigate the utility of using simple quantitative parameters generated with novel synthetic MRI to evaluate bone quality, as well as the correlations of these parameters with DEXA measurements. METHODS This prospective study enrolled patients with symptomatic lumbar degenerative disease who underwent DEXA and conventional and synthetic MRI. The quantitative parameters generated with synthetic MRI were T1 map, T2 map, T1 intensity, proton density (PD), and vertebral bone quality (VBQ) score, and these parameters were correlated with T-score of the lumbar spine. RESULTS There were 62 patients and 238 lumbar segments eligible for analysis. PD and VBQ score moderately correlated with T-score of the lumbar spine (r = -0.565 and -0.651, respectively; both p < 0.001). T1 intensity correlated fairly well with T-score (r = -0.411, p < 0.001). T1 and T2 correlated poorly with T-score. Receiver operating characteristic curve analysis demonstrated area under the curve values of 0.808 and 0.794 for detecting osteopenia/osteoporosis (Tscore ≤ -1.0) and osteoporosis (T-score ≤ -2.5) with PD (both p < 0.001). CONCLUSIONS PD and T1 intensity values generated with synthetic MRI demonstrated significant correlation with T-score. PD has excellent ability for predicting osteoporosis and osteopenia.

Original languageEnglish
Pages (from-to)414-421
Number of pages8
JournalJournal of Neurosurgery: Spine
Issue number3
StatePublished - Mar 2022


  • DEXA
  • Osteoporosis
  • T-score
  • degenerative
  • dual-energy x-ray absorptiometry
  • synthetic MRI
  • vertebral bone quality


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