Simple and Rapid Synthesis of Branched Peptides through Microwave-Assisted On-Bead Ligation

Vijayasimha Molakaseema; Anand Selvaraj; Hui Ting Chen; Yen Wei Chen; Yi Chang Liu; Chai Lin Kao

doi:10.1021/acs.joc.1c01455

Simple and Rapid Synthesis of Branched Peptides through Microwave-Assisted On-Bead Ligation

Vijayasimha Molakaseema, Anand Selvaraj, Hui Ting Chen, Yen Wei Chen, Yi Chang Liu^*, Chai Lin Kao^*

^*Corresponding author for this work

Faculty of Pharmacy

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A rapid on-bead convergent method for preparing branched peptides was reported. Linear peptides were prepared on Dbz resin and ligated various branched cores, including lysine dendrons and other dendritic compounds. Alongside microwave irradiation, <1.5 equiv of peptides is sufficient to afford 50–65% yields of pure branched peptides without chromatographic purification. Remarkably, the desired compounds were prepared within hours.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Journal of Organic Chemistry
Volume	87
Issue number	1
DOIs	https://doi.org/10.1021/acs.joc.1c01455
State	E-pub ahead of print - Oct 2021

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title = "Simple and Rapid Synthesis of Branched Peptides through Microwave-Assisted On-Bead Ligation",

abstract = "A rapid on-bead convergent method for preparing branched peptides was reported. Linear peptides were prepared on Dbz resin and ligated various branched cores, including lysine dendrons and other dendritic compounds. Alongside microwave irradiation, <1.5 equiv of peptides is sufficient to afford 50–65% yields of pure branched peptides without chromatographic purification. Remarkably, the desired compounds were prepared within hours.",

author = "Vijayasimha Molakaseema and Anand Selvaraj and Chen, {Hui Ting} and Chen, {Yen Wei} and Liu, {Yi Chang} and Kao, {Chai Lin}",

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T1 - Simple and Rapid Synthesis of Branched Peptides through Microwave-Assisted On-Bead Ligation

AU - Molakaseema, Vijayasimha

AU - Selvaraj, Anand

AU - Chen, Hui Ting

AU - Chen, Yen Wei

AU - Liu, Yi Chang

AU - Kao, Chai Lin

PY - 2021/10

Y1 - 2021/10

N2 - A rapid on-bead convergent method for preparing branched peptides was reported. Linear peptides were prepared on Dbz resin and ligated various branched cores, including lysine dendrons and other dendritic compounds. Alongside microwave irradiation, <1.5 equiv of peptides is sufficient to afford 50–65% yields of pure branched peptides without chromatographic purification. Remarkably, the desired compounds were prepared within hours.

AB - A rapid on-bead convergent method for preparing branched peptides was reported. Linear peptides were prepared on Dbz resin and ligated various branched cores, including lysine dendrons and other dendritic compounds. Alongside microwave irradiation, <1.5 equiv of peptides is sufficient to afford 50–65% yields of pure branched peptides without chromatographic purification. Remarkably, the desired compounds were prepared within hours.

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DO - 10.1021/acs.joc.1c01455

M3 - Article

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JF - Journal of Organic Chemistry

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Simple and Rapid Synthesis of Branched Peptides through Microwave-Assisted On-Bead Ligation

Abstract

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