Signal properties of split-spectrum amplitude decorrelation angiography for quantitative optical coherence tomography-based velocimetry

YU NAKAMICHI*, KAI SHIH CHIU, CHIA WEI SUN

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Split-spectrum amplitude-decorrelation angiography (SSADA) is a noninvasive and three-dimensional angiographic technique with a microscale spatial resolution based on optical coherence tomography. The SSADA signal is known to be correlated with the blood flow velocity and the quantitative velocimetry with SSADA has been expected; however, the signal properties of SSADA are not completely understood due to lack of comprehensive investigations of parameters related to SSADA signals. In this study, phantom experiments were performed to comprehensively investigate the relation of SSADA signals with flow velocities, time separations, particle concentrations, signal-to-noise ratios, beam spot sizes, and viscosities, and revealed that SSADA signals reflect the spatial commonality within a coherence volume between adjacent A-scans.

Original languageEnglish
Pages (from-to)5955-5968
Number of pages14
JournalBiomedical Optics Express
Volume12
Issue number10
DOIs
StatePublished - 1 Oct 2021

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