Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation

Kuo Li Pan; Ya Wen Hsiao; Yenn Jiang Lin; Li Wei Lo; Yu Feng Hu; Fa Po Chung; Yung Nan Tsai; Tze Fan Chao; Jo Nan Liao; Chin Yu Lin; Shih Jie Jhuo; Chung Hsing Lin; Allamsetty Suresh; Rohit Walia; Abigail Louise D. Te; Shinya Yamada; Yao Ting Chang; Shih Lin Chang; Shih Ann Chen

doi:10.1253/circj.CJ-18-0880

Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation

Kuo Li Pan, Ya Wen Hsiao, Yenn Jiang Lin, Li Wei Lo, Yu Feng Hu, Fa Po Chung, Yung Nan Tsai, Tze Fan Chao, Jo Nan Liao, Chin Yu Lin, Shih Jie Jhuo, Chung Hsing Lin, Allamsetty Suresh, Rohit Walia, Abigail Louise D. Te, Shinya Yamada, Yao Ting Chang, Shih Lin Chang^*, Shih Ann Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation. Methods and Results: A total of 131 participants (26 healthy individuals and 105 symptomatic PAF patients) were enrolled. PAF patients (54.1±10.8 years) who received catheter ablation therapy were divided into 2 groups: recurrent AF (n=25) and no recurrent AF after catheter ablation (n=80). Peripheral blood mononuclear cells were collected from all subjects to measure LTL. Under 50 years old, LTL in healthy individuals (n=17) was longer than in PAF patients (n=31; 7.34±0.58 kbp vs. 6.44±0.91 kbp, P=0.01). In PAF patients, LTL was positively correlated with left atrial bipolar voltage (R=0.497, P<0.001), and negatively correlated with biatrial scar area (R=−0.570, P<0.001) and left atrial diameter (R=−0.214, P=0.028). LTL was shorter in the patients with recurrent AF than in those without recurrent AF after catheter ablation (5.68±0.82 kbp vs. 6.66±0.71 kbp; P<0.001). On receiver operating characteristic curve analysis, LTL cut-off <6.14 kbp had a specificity of 0.68 and sensitivity of 0.79 to predict recurrent AF after catheter ablation. Conclusions: Young PAF patients (≤50 years) had shorter LTL. Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients.

Original language	English
Pages (from-to)	1449-1455
Number of pages	7
Journal	Circulation Journal
Volume	83
Issue number	7
DOIs	https://doi.org/10.1253/circj.CJ-18-0880
State	Published - 2019

Keywords

Atrial fibrillation
Catheter ablation
Leukocyte telomere length

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10.1253/circj.CJ-18-0880

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Pan, K. L., Hsiao, Y. W., Lin, Y. J., Lo, L. W., Hu, Y. F., Chung, F. P., Tsai, Y. N., Chao, T. F., Liao, J. N., Lin, C. Y., Jhuo, S. J., Lin, C. H., Suresh, A., Walia, R., Te, A. L. D., Yamada, S., Chang, Y. T., Chang, S. L., & Chen, S. A. (2019). Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation. Circulation Journal, 83(7), 1449-1455. https://doi.org/10.1253/circj.CJ-18-0880

@article{7d5c8640e7da46c8a87bf0aba9df4d09,

title = "Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation",

abstract = "Background: Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation. Methods and Results: A total of 131 participants (26 healthy individuals and 105 symptomatic PAF patients) were enrolled. PAF patients (54.1±10.8 years) who received catheter ablation therapy were divided into 2 groups: recurrent AF (n=25) and no recurrent AF after catheter ablation (n=80). Peripheral blood mononuclear cells were collected from all subjects to measure LTL. Under 50 years old, LTL in healthy individuals (n=17) was longer than in PAF patients (n=31; 7.34±0.58 kbp vs. 6.44±0.91 kbp, P=0.01). In PAF patients, LTL was positively correlated with left atrial bipolar voltage (R=0.497, P<0.001), and negatively correlated with biatrial scar area (R=−0.570, P<0.001) and left atrial diameter (R=−0.214, P=0.028). LTL was shorter in the patients with recurrent AF than in those without recurrent AF after catheter ablation (5.68±0.82 kbp vs. 6.66±0.71 kbp; P<0.001). On receiver operating characteristic curve analysis, LTL cut-off <6.14 kbp had a specificity of 0.68 and sensitivity of 0.79 to predict recurrent AF after catheter ablation. Conclusions: Young PAF patients (≤50 years) had shorter LTL. Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients.",

keywords = "Atrial fibrillation, Catheter ablation, Leukocyte telomere length",

author = "Pan, {Kuo Li} and Hsiao, {Ya Wen} and Lin, {Yenn Jiang} and Lo, {Li Wei} and Hu, {Yu Feng} and Chung, {Fa Po} and Tsai, {Yung Nan} and Chao, {Tze Fan} and Liao, {Jo Nan} and Lin, {Chin Yu} and Jhuo, {Shih Jie} and Lin, {Chung Hsing} and Allamsetty Suresh and Rohit Walia and Te, {Abigail Louise D.} and Shinya Yamada and Chang, {Yao Ting} and Chang, {Shih Lin} and Chen, {Shih Ann}",

year = "2019",

doi = "10.1253/circj.CJ-18-0880",

language = "English",

volume = "83",

pages = "1449--1455",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "7",

}

Pan, KL, Hsiao, YW, Lin, YJ, Lo, LW , Hu, YF, Chung, FP, Tsai, YN, Chao, TF, Liao, JN, Lin, CY, Jhuo, SJ, Lin, CH, Suresh, A, Walia, R, Te, ALD, Yamada, S, Chang, YT, Chang, SL & Chen, SA 2019, 'Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation', Circulation Journal, vol. 83, no. 7, pp. 1449-1455. https://doi.org/10.1253/circj.CJ-18-0880

TY - JOUR

T1 - Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation

AU - Pan, Kuo Li

AU - Hsiao, Ya Wen

AU - Lin, Yenn Jiang

AU - Lo, Li Wei

AU - Hu, Yu Feng

AU - Chung, Fa Po

AU - Tsai, Yung Nan

AU - Chao, Tze Fan

AU - Liao, Jo Nan

AU - Lin, Chin Yu

AU - Jhuo, Shih Jie

AU - Lin, Chung Hsing

AU - Suresh, Allamsetty

AU - Walia, Rohit

AU - Te, Abigail Louise D.

AU - Yamada, Shinya

AU - Chang, Yao Ting

AU - Chang, Shih Lin

AU - Chen, Shih Ann

PY - 2019

Y1 - 2019

N2 - Background: Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation. Methods and Results: A total of 131 participants (26 healthy individuals and 105 symptomatic PAF patients) were enrolled. PAF patients (54.1±10.8 years) who received catheter ablation therapy were divided into 2 groups: recurrent AF (n=25) and no recurrent AF after catheter ablation (n=80). Peripheral blood mononuclear cells were collected from all subjects to measure LTL. Under 50 years old, LTL in healthy individuals (n=17) was longer than in PAF patients (n=31; 7.34±0.58 kbp vs. 6.44±0.91 kbp, P=0.01). In PAF patients, LTL was positively correlated with left atrial bipolar voltage (R=0.497, P<0.001), and negatively correlated with biatrial scar area (R=−0.570, P<0.001) and left atrial diameter (R=−0.214, P=0.028). LTL was shorter in the patients with recurrent AF than in those without recurrent AF after catheter ablation (5.68±0.82 kbp vs. 6.66±0.71 kbp; P<0.001). On receiver operating characteristic curve analysis, LTL cut-off <6.14 kbp had a specificity of 0.68 and sensitivity of 0.79 to predict recurrent AF after catheter ablation. Conclusions: Young PAF patients (≤50 years) had shorter LTL. Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients.

AB - Background: Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation. Methods and Results: A total of 131 participants (26 healthy individuals and 105 symptomatic PAF patients) were enrolled. PAF patients (54.1±10.8 years) who received catheter ablation therapy were divided into 2 groups: recurrent AF (n=25) and no recurrent AF after catheter ablation (n=80). Peripheral blood mononuclear cells were collected from all subjects to measure LTL. Under 50 years old, LTL in healthy individuals (n=17) was longer than in PAF patients (n=31; 7.34±0.58 kbp vs. 6.44±0.91 kbp, P=0.01). In PAF patients, LTL was positively correlated with left atrial bipolar voltage (R=0.497, P<0.001), and negatively correlated with biatrial scar area (R=−0.570, P<0.001) and left atrial diameter (R=−0.214, P=0.028). LTL was shorter in the patients with recurrent AF than in those without recurrent AF after catheter ablation (5.68±0.82 kbp vs. 6.66±0.71 kbp; P<0.001). On receiver operating characteristic curve analysis, LTL cut-off <6.14 kbp had a specificity of 0.68 and sensitivity of 0.79 to predict recurrent AF after catheter ablation. Conclusions: Young PAF patients (≤50 years) had shorter LTL. Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients.

KW - Atrial fibrillation

KW - Catheter ablation

KW - Leukocyte telomere length

UR - http://www.scopus.com/inward/record.url?scp=85068601009&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-18-0880

DO - 10.1253/circj.CJ-18-0880

M3 - Article

C2 - 31118363

AN - SCOPUS:85068601009

SN - 1346-9843

VL - 83

SP - 1449

EP - 1455

JO - Circulation Journal

JF - Circulation Journal

IS - 7

ER -

Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation

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