Shorter antibiotic regimens impact the control efforts in high tuberculosis burden regions of Taiwan

Yi Jun Lin, Hsing Chieh Lin, Ying Fei Yang, Chi Yun Chen, Tien Hsuan Lu, Chung Min Liao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objectives: To assess the potential epidemiological impact and cost-effectiveness of shorter antibiotic regimens in high tuberculosis (TB) burden regions of Taiwan. Methods: This study combined the TB population dynamic model and cost-effectiveness analysis with local data to simulate the disease burdens, effectiveness and costs of hypothetical 4-month, 2-month and 7-day regimens compared with the standard regimen. Results: The main outcomes were the potential of shorter regimens for averted incidence, mortality and disability-adjusted life years, incremental cost-effectiveness ratio and net monetary benefit. Shorter regimens would lower incidence rates and mortality cases in a high TB burden region by an average of 19–33% and 27–41%, respectively, with the potential for cost-effectiveness or cost-saving. The 2-month and 7-day regimens would be more cost-effective than the 4-month regimen. The threshold daily drug prices for achieving cost-effectiveness and cost-saving for 4-month, 2-month and 7-day regimens were $US1, $US2 and $US70, respectively. Such cost-effectiveness would remain, even if the willingness-to-pay threshold was less than one gross domestic product per capita. Conclusions: The findings support the inclusion of shorter regimens in global guidelines and regional-scale TB control strategies, which would improve disease control, particularly in settings with high rates of incidence and poor treatment outcomes.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalInternational Journal of Infectious Diseases
StatePublished - Aug 2020


  • Antibiotic treatment
  • Economic evaluation
  • Population dynamic model
  • Shorter regimens
  • Tuberculosis


Dive into the research topics of 'Shorter antibiotic regimens impact the control efforts in high tuberculosis burden regions of Taiwan'. Together they form a unique fingerprint.

Cite this