Short term vs. long term test-retest reproducibility of 123I-ADAM for the binding of serotonin transporters in the human brain

Ju Wei Hsu, Shyh Jen Wang, Chun Lung Lin, Wen Chi Hsieh, Jiing Feng Lirng, Yuh Chiang Shen, Mei Hsiu Liao, Yuan Hwa Chou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Previous brain imaging studies have demonstrated a seasonal difference of serotonin transporter (SERT) binding in the human brain. However, the results were somewhat contradictory. We conducted test-retest study with single photon emission computed tomography (SPECT) with 123I-ADAM as ligand in 28 healthy subjects. Ten of the subjects were studied within 1month, whereas 18 were randomly assigned to be studied over a period of up to 1year. The primary measure was the specific uptake ratio (SUR). Regions of interest included the midbrain, thalamus, putamen and caudate. The intra-class correlation coefficient (ICC) was 0.52-0.94 across different brain regions over 1month, whereas the ICC was -0.24-0.63 over a 1-year period. The 1-month variability ranged from 6.5±5.1% to 12.5±10.6% across different brain regions, and the 1-year variability ranged from 16.5±9.6% to 41.9±35.5%. The Kruskal-Wallis test revealed a significant difference of variability across months. The Wilcoxon Signed Ranks Test showed the SUR between test-retest scans was of borderline significance. Curve fitting, using a 4th degree polynomial model, revealed a significant circadian correlation between the variability and interval of test-retest measurements. Our findings demonstrate the test-retest reproducibility of 123I-ADAM in different time periods and suggest that circadian variation of SERT levels in the human brain might exist.

Original languageEnglish
Pages (from-to)224-229
Number of pages6
JournalPsychiatry Research - Neuroimaging
Volume194
Issue number3
DOIs
StatePublished - 30 Dec 2011

Keywords

  • Circadian variation
  • Healthy subject
  • I-ADAM
  • Reproducibility
  • SPECT
  • Serotonin transporter

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