Self-Assembly of the Tetraphenylethylene-Capped Diserine through a Hierarchical Assembly Process

Jui Wen Chang, Rajan Deepan Chakravarthy, Nien Tzu Chu, Jyun Cheng Liu, Mei Yu Yeh*, Hsin Chieh Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We report a new peptide-based urchin-shaped structure prepared through two-step self-assembly of tetraphenylethylene-diserine (TPE-SS). Hydrogelation generated nanobelts through the first stage of self-assembly of TPE-SS; these nanobelts further transformed on silicon wafers into urchin-like microstructures featuring nanosized spines. The presence of the TPE moiety in the hydrogelator resulted in aggregation-induced emission characteristics both in the solution and in the gel phases. TPE-SS has the lowest molecular weight of any TPE-capped hydrogelator with β-sheet-like structures under physiological pH. This new design strategy appears to be useful for generating three-dimensional self-assembled microstructures and multifunctional biomaterials. We found that TPE-SS is biocompatible with human mesenchymal stem cells and breast cancer cells, making them potential applications in tissue engineering and biomedical research.

Original languageEnglish
Pages (from-to)562-571
Number of pages10
JournalBioconjugate Chemistry
Volume34
Issue number3
DOIs
StatePublished - 15 Mar 2023

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