TY - JOUR
T1 - Self-assembly of a micelle structure from graft and diblock copolymers
T2 - An example of overcoming the limitations of polyions in drug delivery
AU - Lo, Chun Liang
AU - Lin, Ko Min
AU - Huang, Chun Kai
AU - Hsiue, Ging Ho
PY - 2006/12/4
Y1 - 2006/12/4
N2 - A novel mixed micelle with a multifunctional core and shell is successfully prepared from a graft copolymer, poly(N-isopropyl acrylamide-co-methacrylic acid)-g-poly(D,L-lactide) (P(NIPAAm-co-MAAc)-g-PLA) and two diblock copolymers, poly(ethylene glycol)-b-poly(D,L-lactide) and poly (2-ethyl-2-oxazoline)-b- poly(D,L-lactide). This nanostructure completely screens the highly negative charges of the graft copolymer and exhibits multifunctionality because it has a specialized core/shell structure. An example of this micelle structure used in intracellular drug delivery demonstrates a strong relationship between drug release and the functionality of the mixed micelle. Additionally, the efficiency of the screening feature is also displayed in the cytotoxicities; mixed micelles exhibit higher drug activity and lower material cytotoxicity than micelles from P(NIPAAm-co-MAAc)-g-PLA ([NIPAAm]/[MAAc]/[PLA] = 84:5.9:2.5 mol/mol) copolymer. This study not only presents a new micelle structure generated using a graft-diblock copolymer system, but also elucidates concepts upon which the preparation of a multifunctional micelle from a graft copolymer with a single (or many) diblock copolymer(s) can be based for applications in drug delivery.
AB - A novel mixed micelle with a multifunctional core and shell is successfully prepared from a graft copolymer, poly(N-isopropyl acrylamide-co-methacrylic acid)-g-poly(D,L-lactide) (P(NIPAAm-co-MAAc)-g-PLA) and two diblock copolymers, poly(ethylene glycol)-b-poly(D,L-lactide) and poly (2-ethyl-2-oxazoline)-b- poly(D,L-lactide). This nanostructure completely screens the highly negative charges of the graft copolymer and exhibits multifunctionality because it has a specialized core/shell structure. An example of this micelle structure used in intracellular drug delivery demonstrates a strong relationship between drug release and the functionality of the mixed micelle. Additionally, the efficiency of the screening feature is also displayed in the cytotoxicities; mixed micelles exhibit higher drug activity and lower material cytotoxicity than micelles from P(NIPAAm-co-MAAc)-g-PLA ([NIPAAm]/[MAAc]/[PLA] = 84:5.9:2.5 mol/mol) copolymer. This study not only presents a new micelle structure generated using a graft-diblock copolymer system, but also elucidates concepts upon which the preparation of a multifunctional micelle from a graft copolymer with a single (or many) diblock copolymer(s) can be based for applications in drug delivery.
UR - http://www.scopus.com/inward/record.url?scp=33845872588&partnerID=8YFLogxK
U2 - 10.1002/adfm.200500627
DO - 10.1002/adfm.200500627
M3 - Article
AN - SCOPUS:33845872588
SN - 1616-301X
VL - 16
SP - 2309
EP - 2316
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 18
ER -