TY - JOUR
T1 - Sarcopenia, but not sarcopenic obesity, predicts mortality for older old men
T2 - A 3-year prospective cohort study
AU - Liu, Li Kuo
AU - Chen, Liang Yu
AU - Yeh, Kuo Ping
AU - Lin, Ming Hsien
AU - Hwang, An Chun
AU - Peng, Li Ning
AU - Chen, Liang Kung
N1 - Funding Information:
This study was supported by the Veteran Affairs Commission, Executive Yuan, the Republic of China (Taipei, Taiwan) and by the Aging and Health Research Center of National Yang Ming University (Taipei, Taiwan).
PY - 2014/6
Y1 - 2014/6
N2 - Background The prognostic significance of sarcopenia and sarcopenic obesity (SO) among older people remains controversial. The main aim of this study was to evaluate the mortality risk of sarcopenia and SO among men aged 75 years and older in Taiwan. Methods This prospective cohort study recruited all residents of the Banciao Veterans Home, a veterans retirement community in Taipei City in northern Taiwan. For all study participants, the demographic profile, comorbid medical conditions, biochemical markers, handgrip strength and gait speed, sarcopenia, SO, and all-cause mortality were collected during a 3-year follow-up period. Results In the study, 680 residents participated. The prevalence of sarcopenia and SO was 60.3% and 19.7%, respectively. During the study period, 140 (20.6%) deaths were identified. The diseased individuals were older, more prone to having diabetes mellitus and sarcopenia, had lower serum levels of total cholesterol and triglycerides, but had no difference in SO. Comparisons between different statuses of SO showed that age; diabetes mellitus; metabolic syndrome; body mass index; waist circumference; handgrip strength; gait speed; systolic blood pressure; fasting plasma glucose; serum levels of total cholesterol, triglyceride, high-density lipoprotein; and mortality were all significantly different between the groups. Sarcopenia [odds ratio (OR), 2.64; 95% confidence interval (C.I.), 1.687-4.135; p < 0.001], diabetes mellitus (OR, 1.70; 95% CI, 1.083-2.267; p = 0.021) were independent risk factors for mortality; whereas the serum level of triglyceride was protective (OR, 0.99; 95% CI, 0.989-0.997; p = 0.001). The Cox proportional hazard model confirmed that sarcopenia was significantly associated with mortality with or without obesity. Conclusion The mortality risk of sarcopenia significantly outweighed the survival benefits of obesity in old age. The unfavorable impact of SO may eventually result from sarcopenia, but not obesity.
AB - Background The prognostic significance of sarcopenia and sarcopenic obesity (SO) among older people remains controversial. The main aim of this study was to evaluate the mortality risk of sarcopenia and SO among men aged 75 years and older in Taiwan. Methods This prospective cohort study recruited all residents of the Banciao Veterans Home, a veterans retirement community in Taipei City in northern Taiwan. For all study participants, the demographic profile, comorbid medical conditions, biochemical markers, handgrip strength and gait speed, sarcopenia, SO, and all-cause mortality were collected during a 3-year follow-up period. Results In the study, 680 residents participated. The prevalence of sarcopenia and SO was 60.3% and 19.7%, respectively. During the study period, 140 (20.6%) deaths were identified. The diseased individuals were older, more prone to having diabetes mellitus and sarcopenia, had lower serum levels of total cholesterol and triglycerides, but had no difference in SO. Comparisons between different statuses of SO showed that age; diabetes mellitus; metabolic syndrome; body mass index; waist circumference; handgrip strength; gait speed; systolic blood pressure; fasting plasma glucose; serum levels of total cholesterol, triglyceride, high-density lipoprotein; and mortality were all significantly different between the groups. Sarcopenia [odds ratio (OR), 2.64; 95% confidence interval (C.I.), 1.687-4.135; p < 0.001], diabetes mellitus (OR, 1.70; 95% CI, 1.083-2.267; p = 0.021) were independent risk factors for mortality; whereas the serum level of triglyceride was protective (OR, 0.99; 95% CI, 0.989-0.997; p = 0.001). The Cox proportional hazard model confirmed that sarcopenia was significantly associated with mortality with or without obesity. Conclusion The mortality risk of sarcopenia significantly outweighed the survival benefits of obesity in old age. The unfavorable impact of SO may eventually result from sarcopenia, but not obesity.
KW - All-cause mortality
KW - Elderly
KW - Frailty
KW - Sarcopenia
KW - Sarcopenic obesity
UR - http://www.scopus.com/inward/record.url?scp=84901627003&partnerID=8YFLogxK
U2 - 10.1016/j.jcgg.2014.01.002
DO - 10.1016/j.jcgg.2014.01.002
M3 - Article
AN - SCOPUS:84901627003
SN - 2210-8335
VL - 5
SP - 42
EP - 46
JO - Journal of Clinical Gerontology and Geriatrics
JF - Journal of Clinical Gerontology and Geriatrics
IS - 2
ER -