TY - JOUR
T1 - Sarcomas and sarcomatoid tumor after radiotherapy of oral squamous cell carcinoma
T2 - analysis of 4 cases
AU - Chen, Ya Wei
AU - Tu, Hsi Fen
AU - Wu, Tsen Hsian
AU - Lo, Wen Liang
AU - Chang, Che Shoa
AU - Chang, Kuo Wei
AU - Kao, Shou Yen
N1 - Funding Information:
This article was sponsored by VGH93C230, NSC 93-3112B075, and CI937 grants, Taiwan, ROC.
PY - 2008/1
Y1 - 2008/1
N2 - Radiation-induced sarcoma (RIS) or postirradiation sarcoma has been reported rarely as a long-term complication of radiation therapy (RT). We report 4 cases of oral sarcomas or sarcomatoid tumors with a rather short latency period after radiotherapy of the prior OSCC. Histopathological evaluation and immunohistochemical study were performed using a panel of markers including vimentin, cytokeratin, S-100, desmin, myoglobin, HHF-35, p53, and p16. All reported cases were positive for vimentin and negative for cytokeratin. Two cases were positive for myoglobin, desmin, or HHF-35, and were probably myogenic origin. One case was possibly a fibrosarcoma and the subclassification of the other one was not specified. Diverse expression of p53 and p16 was further observed in these 4 cases. Report of the complicated clinical processes and the analysis of genetic markers of these cases provide useful clinical and pathogenetic insights of mesenchymal malignancies associated with a status post OSCC radiation.
AB - Radiation-induced sarcoma (RIS) or postirradiation sarcoma has been reported rarely as a long-term complication of radiation therapy (RT). We report 4 cases of oral sarcomas or sarcomatoid tumors with a rather short latency period after radiotherapy of the prior OSCC. Histopathological evaluation and immunohistochemical study were performed using a panel of markers including vimentin, cytokeratin, S-100, desmin, myoglobin, HHF-35, p53, and p16. All reported cases were positive for vimentin and negative for cytokeratin. Two cases were positive for myoglobin, desmin, or HHF-35, and were probably myogenic origin. One case was possibly a fibrosarcoma and the subclassification of the other one was not specified. Diverse expression of p53 and p16 was further observed in these 4 cases. Report of the complicated clinical processes and the analysis of genetic markers of these cases provide useful clinical and pathogenetic insights of mesenchymal malignancies associated with a status post OSCC radiation.
UR - http://www.scopus.com/inward/record.url?scp=37249033373&partnerID=8YFLogxK
U2 - 10.1016/j.tripleo.2007.01.035
DO - 10.1016/j.tripleo.2007.01.035
M3 - Article
C2 - 17507260
AN - SCOPUS:37249033373
SN - 1079-2104
VL - 105
SP - 65
EP - 71
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 1
ER -