Sample preparation for droplet-based microfluidics

Juinn Dar Huang, Chia Hung Liu

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    1 Scopus citations

    Abstract

    Sample preparation plays an essential role in most biochemical reactions. Raw reactants are diluted to solutions with desirable concentration values in this process. In this paper, a survey of existing techniques addressing sample preparation on digital microfluidic biochips (DMFBs) is given. The fundamentals of DMFBs are introduced first. Next, we explain how dilution operations are performed on DMFBs and how the constraint on mixing models comes due to the DMFB architecture limit. Then, we divide the existing techniques into four groups according to the count of target concentration values as well as the number of different reactant types, and briefly introduce selected major research works in each category.

    Original languageEnglish
    Title of host publicationProceedings of the 14th International Symposium on Integrated Circuits, ISIC 2014
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Pages364-367
    Number of pages4
    ISBN (Electronic)9781479948338
    DOIs
    StatePublished - 2 Feb 2015
    Event14th International Symposium on Integrated Circuits, ISIC 2014 - Singapore, Singapore
    Duration: 10 Dec 201412 Dec 2014

    Publication series

    NameProceedings of the 14th International Symposium on Integrated Circuits, ISIC 2014

    Conference

    Conference14th International Symposium on Integrated Circuits, ISIC 2014
    Country/TerritorySingapore
    CitySingapore
    Period10/12/1412/12/14

    Keywords

    • Biochip
    • digital microfluidic biochip (DMFB)
    • dilution
    • lab-on-a-chip (LoC)
    • sample preparation

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