Roll-to-Roll Gravure Printed Electrochemical Sensors for Wearable and Medical Devices

Mallika Bariya, Ziba Shahpar, Hyejin Park, Junfeng Sun, Younsu Jung, Wei Gao, Hnin Yin Yin Nyein, Tiffany Sun Liaw, Li Chia Tai, Quynh P. Ngo, Minghan Chao, Yingbo Zhao, Mark Hettick, Gyoujin Cho*, Ali Javey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

245 Scopus citations


As recent developments in noninvasive biosensors spearhead the thrust toward personalized health and fitness monitoring, there is a need for high throughput, cost-effective fabrication of flexible sensing components. Toward this goal, we present roll-to-roll (R2R) gravure printed electrodes that are robust under a range of electrochemical sensing applications. We use inks and electrode morphologies designed for electrochemical and mechanical stability, achieving devices with uniform redox kinetics printed on 150 m flexible substrate rolls. We show that these electrodes can be functionalized into consistently high performing sensors for detecting ions, metabolites, heavy metals, and other small molecules in noninvasively accessed biofluids, including sensors for real-time, in situ perspiration monitoring during exercise. This development of robust and versatile R2R gravure printed electrodes represents a key translational step in enabling large-scale, low-cost fabrication of disposable wearable sensors for personalized health monitoring applications.

Original languageEnglish
Pages (from-to)6978-6987
Number of pages10
JournalACS Nano
Issue number7
StatePublished - 24 Jul 2018


  • flexible electronics
  • gravure printing
  • in situ analysis
  • multiplexed sensing
  • roll-to-roll processing
  • wearable biosensors


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