Roles of 5-HT2B Receptor in Pain

Wei Hsin Sun*, Yeu Shiuan Su

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Serotonin can be released from many different types of immune cells and platelets and is related to inflammatory responses. Growing evidence has suggested that serotonin is a pro-nociceptive agent that can cause pain and hyperalgesia by activating various subtypes of 5-HT receptors present in primary afferents. Different subtype receptors on nociceptors have distinct mechanisms in regulating 5-HT–induced pain or hyperalgesia. In this chapter, we focus on the roles of the 5-HT2B receptor in various types of pain and how it regulates pain by distinct mechanisms in various types of pain.

Original languageEnglish
Title of host publicationReceptors
PublisherHumana Press Inc.
Pages143-152
Number of pages10
DOIs
StatePublished - Mar 2021

Publication series

NameReceptors
Volume35
ISSN (Print)1048-6909
ISSN (Electronic)2524-6488

Keywords

  • Mechanical hyperalgesia
  • Neuropathic pain
  • Pain
  • Serotonin
  • TRPV1

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