Roles of 5-HT2B Receptor in Pain

Wei Hsin Sun*, Yeu Shiuan Su

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Serotonin can be released from many different types of immune cells and platelets and is related to inflammatory responses. Growing evidence has suggested that serotonin is a pro-nociceptive agent that can cause pain and hyperalgesia by activating various subtypes of 5-HT receptors present in primary afferents. Different subtype receptors on nociceptors have distinct mechanisms in regulating 5-HT–induced pain or hyperalgesia. In this chapter, we focus on the roles of the 5-HT2B receptor in various types of pain and how it regulates pain by distinct mechanisms in various types of pain.

Original languageEnglish
Title of host publicationReceptors
PublisherHumana Press Inc.
Number of pages10
StatePublished - Mar 2021

Publication series

ISSN (Print)1048-6909
ISSN (Electronic)2524-6488


  • Mechanical hyperalgesia
  • Neuropathic pain
  • Pain
  • Serotonin
  • TRPV1


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