Role of preoperative malnutrition and symptom severity in anorexia-cachexia-related quality of life in patients with operable pancreatic cancer

Yun Jen Chou, Yan Ting Liou, Sheng Ru Lai, Yu Wen Tien, Hsuan Ju Kuo, Hui Ying Yang, Shiow Ching Shun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: This study assessed the changes in malnutrition status, symptom severity, and anorexia-cachexia-related quality of life (QoL) before and after pancreatic surgery and identified significant factors associated with changes in anorexia–cachexia-related QoL in patients with operable pancreatic cancer. Methods: In total, 76 patients with pancreatic cancer who were scheduled to undergo surgery were recruited from a medical center in northern Taiwan. The Mini Nutritional Assessment, Symptom Severity Scale, and Functional Assessment of Anorexia–Cachexia Therapy scale were used to assess the patients’ nutritional status, symptom severity, and anorexia–cachexia-related QoL, respectively. Bioelectrical impedance analysis was performed using X-Scan Plus II to assess body composition. A generalized estimating equation approach was used to identify significant factors associated with anorexia–cachexia-related QoL. Results: In total, 42.1% of the patients had malnutrition or were at risk of malnutrition before surgery. Preoperative malnutrition (β = −3.857, p = .001) and higher early satiety (β = −0.629, p = .005), insomnia (β = −0.452, p = .025), and pain (β = −0.779, p < .001) were associated with lower anorexia-cachexia-related QoL. Conclusion: Clinicians should actively assess the nutritional status of patients with pancreatic cancer before surgery and provide symptom cluster management interventions to improve nutrition, insomnia, and pain, which is crucial for enhancing patients’ anorexia–cachexia-related QoL.

Original languageEnglish
Article number102352
JournalEuropean Journal of Oncology Nursing
Volume66
DOIs
StatePublished - Oct 2023

Keywords

  • Body composition
  • Pancreatectomy
  • Pancreatic cancer
  • Preoperative malnutrition
  • Quality of life
  • Symptom severity

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