Role of pigment epithelium-derived factor in stem/progenitor cell-associated neovascularization

Jung Tung Liu, Yuh Lien Chen, Wen Chi Chen, Huey Yi Chen, Yi Wen Lin, Shu Huei Wang, Kee Ming Man, Hui Min Wan, Wei Hsian Yin, Po Len Liu*, Yung Hsiang Chen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Pigment epithelium-derived factor (PEDF) was first identified in retinal pigment epithelium cells. It is an endogenously produced protein that is widely expressed throughout the human body such as in the eyes, liver, heart, and adipose tissue; it exhibits multiple and varied biological activities. PEDF is a multifunctional protein with antiangiogenic, antitumorigenic, antioxidant, anti-inflammatory, antithrombotic, neurotrophic, and neuroprotective properties. More recently, PEDF has been shown to be the most potent inhibitor of stem/progenitor cell-associated neovascularization. Neovascularization is a complex process regulated by a large, interacting network of molecules from stem/progenitor cells. PEDF is also involved in the pathogenesis of angiogenic eye disease, tumor growth, and cardiovascular disease. Novel antiangiogenic agents with tolerable side effects are desired for the treatment of patients with various diseases. Here, we review the value of PEDF as an important endogenous antiangiogenic molecule; we focus on the recently identified role of PEDF as a possible new target molecule to influence stem/progenitor cell-related neovascularization.

Original languageEnglish
Article number871272
JournalJournal of Biomedicine and Biotechnology
StatePublished - 2012


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