Risk of type 2 diabetes mellitus between adolescents with antidepressant-resistant and antidepressant-responsive depression: A cohort study of 15,651 adolescents

Ju Wei Hsu, Li Chi Chen, Kai Lin Huang, Shih Jen Tsai, Ya Mei Bai, Tung Ping Su, Tzeng-Ji Chen, Mu Hong Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Whether response to antidepressants is related to the risk of developing type 2 diabetes mellitus (T2DM) in adolescents with depression remains unknown. Methods: This study used the Taiwan National Health Insurance Research Database to enroll 1739 adolescents with antidepressant-resistant depression, 6956 with antidepressant-responsive depression, and 6956 controls between 2001 and 2010, with an end-of-2011 follow-up. Physician-diagnosed T2DM was identified at follow-up. T2DM-related risk factors, namely hypertension, dyslipidemia, and obesity, were assessed and controlled for as confounding factors. Results: Adolescents with antidepressant-resistant depression (hazard ratio [HR], 95 % confidence interval [CI]: 4.62, 2.75–7.75) and those with antidepressant-responsive depression (HR, 95 % CI: 3.06, 1.98–4.72) had a higher risk of developing T2DM at follow-up than did the control group. Those with antidepressant-resistant depression were more likely to receive a diagnosis of T2DM (HR, 95 % CI: 1.51, 1.04–2.19) later in life than were those with antidepressant-responsive depression. Discussion: Clinicians should closely monitor factors related to T2DM, such as fasting blood sugar, in high-risk populations, especially in adolescents with antidepressant-resistant depression.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalJournal of Affective Disorders
Volume328
DOIs
StatePublished - 1 May 2023

Keywords

  • Adolescent depression
  • Antidepressant-resistant depression
  • Antidepressant-responsive depression
  • Type 2 diabetes mellitus

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