Risk of cancer in patients with cholecystitis: A nationwide population-based study

Pei Chang Lee; Yu Wen Hu; Li Yu Hu; San Chi Chen; Sheng Hsuan Chien; Cheng Che Shen; Chiu Mei Yeh; Chun Chia Chen; Han Chieh Lin; Sang Hue Yen; Cheng Hwai Tzeng; Tzeng Ji Chen; Chia Jen Liu

doi:10.1016/j.amjmed.2014.08.036

Risk of cancer in patients with cholecystitis: A nationwide population-based study

Pei Chang Lee, Yu Wen Hu, Li Yu Hu, San Chi Chen, Sheng Hsuan Chien, Cheng Che Shen, Chiu Mei Yeh, Chun Chia Chen, Han Chieh Lin, Sang Hue Yen, Cheng Hwai Tzeng, Tzeng Ji Chen, Chia Jen Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

OBJECTIVE: The objective of this study was to evaluate the risk of cancer in patients diagnosed with cholecystitis and possible interactions between cholecystitis and cholecystectomy. METHODS: A retrospective population-based cohort study was conducted among patients diagnosed with cholecystitis that were registered in the National Health Insurance Research Database in Taiwan between January 1, 2000 and December 31, 2010. Standardized incidence ratios (SIRs) were calculated to compare the incidence of cancer in these patients to that of the general population. Adjusted hazard ratios (HRs) were also calculated to investigate whether cholecystitis increased the risk for specific cancers. RESULTS: During a median observation period of 5.4 years, 1541 cancers occurred in 20,431 patients with cholecystitis, yielding a SIR of 1.97 (95% confidence interval [CI], 1.88-2.07). A significantly greater risk of biliary tract cancer (adjusted HR 1.72; 95% CI, 1.08-2.75) was observed after adjusting for potential risk factors. In contrast, cholecystectomy was found to attenuate the cancer risk, with the reduction of adjusted HR from 2.34 (95% CI, 1.62-3.37) to 1.28 (95% CI, 0.76-2.14). CONCLUSION: Cholecystitis is an independent risk factor to extrahepatic biliary tract cancers, whereas cholecystectomy can attenuate the cancer risk of cholecystitis.

Original language	English
Pages (from-to)	185-191
Number of pages	7
Journal	American Journal of Medicine
Volume	128
Issue number	2
DOIs	https://doi.org/10.1016/j.amjmed.2014.08.036
State	Published - 1 Feb 2015

Keywords

Cancer risk
Cholecystectomy
Cholecystitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.amjmed.2014.08.036

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@article{c2cea4e1dfd0436f8b21130c47ae1236,

title = "Risk of cancer in patients with cholecystitis: A nationwide population-based study",

abstract = "OBJECTIVE: The objective of this study was to evaluate the risk of cancer in patients diagnosed with cholecystitis and possible interactions between cholecystitis and cholecystectomy. METHODS: A retrospective population-based cohort study was conducted among patients diagnosed with cholecystitis that were registered in the National Health Insurance Research Database in Taiwan between January 1, 2000 and December 31, 2010. Standardized incidence ratios (SIRs) were calculated to compare the incidence of cancer in these patients to that of the general population. Adjusted hazard ratios (HRs) were also calculated to investigate whether cholecystitis increased the risk for specific cancers. RESULTS: During a median observation period of 5.4 years, 1541 cancers occurred in 20,431 patients with cholecystitis, yielding a SIR of 1.97 (95% confidence interval [CI], 1.88-2.07). A significantly greater risk of biliary tract cancer (adjusted HR 1.72; 95% CI, 1.08-2.75) was observed after adjusting for potential risk factors. In contrast, cholecystectomy was found to attenuate the cancer risk, with the reduction of adjusted HR from 2.34 (95% CI, 1.62-3.37) to 1.28 (95% CI, 0.76-2.14). CONCLUSION: Cholecystitis is an independent risk factor to extrahepatic biliary tract cancers, whereas cholecystectomy can attenuate the cancer risk of cholecystitis.",

keywords = "Cancer risk, Cholecystectomy, Cholecystitis",

author = "Lee, {Pei Chang} and Hu, {Yu Wen} and Hu, {Li Yu} and Chen, {San Chi} and Chien, {Sheng Hsuan} and Shen, {Cheng Che} and Yeh, {Chiu Mei} and Chen, {Chun Chia} and Lin, {Han Chieh} and Yen, {Sang Hue} and Tzeng, {Cheng Hwai} and Chen, {Tzeng Ji} and Liu, {Chia Jen}",

year = "2015",

month = feb,

day = "1",

doi = "10.1016/j.amjmed.2014.08.036",

language = "English",

volume = "128",

pages = "185--191",

journal = "American Journal of Medicine",

issn = "0002-9343",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Risk of cancer in patients with cholecystitis

T2 - A nationwide population-based study

AU - Lee, Pei Chang

AU - Hu, Yu Wen

AU - Hu, Li Yu

AU - Chen, San Chi

AU - Chien, Sheng Hsuan

AU - Shen, Cheng Che

AU - Yeh, Chiu Mei

AU - Chen, Chun Chia

AU - Lin, Han Chieh

AU - Yen, Sang Hue

AU - Tzeng, Cheng Hwai

AU - Chen, Tzeng Ji

AU - Liu, Chia Jen

PY - 2015/2/1

Y1 - 2015/2/1

N2 - OBJECTIVE: The objective of this study was to evaluate the risk of cancer in patients diagnosed with cholecystitis and possible interactions between cholecystitis and cholecystectomy. METHODS: A retrospective population-based cohort study was conducted among patients diagnosed with cholecystitis that were registered in the National Health Insurance Research Database in Taiwan between January 1, 2000 and December 31, 2010. Standardized incidence ratios (SIRs) were calculated to compare the incidence of cancer in these patients to that of the general population. Adjusted hazard ratios (HRs) were also calculated to investigate whether cholecystitis increased the risk for specific cancers. RESULTS: During a median observation period of 5.4 years, 1541 cancers occurred in 20,431 patients with cholecystitis, yielding a SIR of 1.97 (95% confidence interval [CI], 1.88-2.07). A significantly greater risk of biliary tract cancer (adjusted HR 1.72; 95% CI, 1.08-2.75) was observed after adjusting for potential risk factors. In contrast, cholecystectomy was found to attenuate the cancer risk, with the reduction of adjusted HR from 2.34 (95% CI, 1.62-3.37) to 1.28 (95% CI, 0.76-2.14). CONCLUSION: Cholecystitis is an independent risk factor to extrahepatic biliary tract cancers, whereas cholecystectomy can attenuate the cancer risk of cholecystitis.

AB - OBJECTIVE: The objective of this study was to evaluate the risk of cancer in patients diagnosed with cholecystitis and possible interactions between cholecystitis and cholecystectomy. METHODS: A retrospective population-based cohort study was conducted among patients diagnosed with cholecystitis that were registered in the National Health Insurance Research Database in Taiwan between January 1, 2000 and December 31, 2010. Standardized incidence ratios (SIRs) were calculated to compare the incidence of cancer in these patients to that of the general population. Adjusted hazard ratios (HRs) were also calculated to investigate whether cholecystitis increased the risk for specific cancers. RESULTS: During a median observation period of 5.4 years, 1541 cancers occurred in 20,431 patients with cholecystitis, yielding a SIR of 1.97 (95% confidence interval [CI], 1.88-2.07). A significantly greater risk of biliary tract cancer (adjusted HR 1.72; 95% CI, 1.08-2.75) was observed after adjusting for potential risk factors. In contrast, cholecystectomy was found to attenuate the cancer risk, with the reduction of adjusted HR from 2.34 (95% CI, 1.62-3.37) to 1.28 (95% CI, 0.76-2.14). CONCLUSION: Cholecystitis is an independent risk factor to extrahepatic biliary tract cancers, whereas cholecystectomy can attenuate the cancer risk of cholecystitis.

KW - Cancer risk

KW - Cholecystectomy

KW - Cholecystitis

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DO - 10.1016/j.amjmed.2014.08.036

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C2 - 25447627

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SN - 0002-9343

VL - 128

SP - 185

EP - 191

JO - American Journal of Medicine

JF - American Journal of Medicine

IS - 2

ER -

Risk of cancer in patients with cholecystitis: A nationwide population-based study

Abstract

Keywords

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