Risk of Autism Associated With General Anesthesia During Cesarean Delivery: A Population-Based Birth-Cohort Analysis

Li Nien Chien; Hsiu Chen Lin; Yu Hsuan Joni Shao; Shu Ti Chiou; Hung Yi Chiou

doi:10.1007/s10803-014-2247-y

Risk of Autism Associated With General Anesthesia During Cesarean Delivery: A Population-Based Birth-Cohort Analysis

Li Nien Chien, Hsiu Chen Lin, Yu Hsuan Joni Shao, Shu Ti Chiou, Hung Yi Chiou^*

^*Corresponding author for this work

Institute of Health and Welfare Policy

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The rates of Cesarean delivery (C-section) have risen to >30 % in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the risk of autism associated with C-section and obstetric anesthesia. During a mean follow-up of 4.3 years, the incidence of autism was higher in neonates delivered by C-section with GA than in neonates delivered vaginally, with an adjusted risk of 1.52 (95 % confidence interval 1.18–1.94). However, the adjusted risk of autism in neonates delivered by C-section with RA and in neonates delivered vaginally was nonsignificantly different.

Original language	English
Pages (from-to)	932-942
Number of pages	11
Journal	Journal of Autism and Developmental Disorders
Volume	45
Issue number	4
DOIs	https://doi.org/10.1007/s10803-014-2247-y
State	Published - 20 Mar 2015

Keywords

Autism
Cesarean delivery
Obstetric anesthesia
Population-based birth cohort

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title = "Risk of Autism Associated With General Anesthesia During Cesarean Delivery: A Population-Based Birth-Cohort Analysis",

abstract = "The rates of Cesarean delivery (C-section) have risen to >30 % in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the risk of autism associated with C-section and obstetric anesthesia. During a mean follow-up of 4.3 years, the incidence of autism was higher in neonates delivered by C-section with GA than in neonates delivered vaginally, with an adjusted risk of 1.52 (95 % confidence interval 1.18–1.94). However, the adjusted risk of autism in neonates delivered by C-section with RA and in neonates delivered vaginally was nonsignificantly different.",

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AU - Chiou, Shu Ti

AU - Chiou, Hung Yi

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Risk of Autism Associated With General Anesthesia During Cesarean Delivery: A Population-Based Birth-Cohort Analysis

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Keywords

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