Risk factors and psychological impact of syncope in migraine patients

Ai Seon Kuan, Shih Pin Chen, Yen Feng Wang, Jong Ling Fuh, Chun Yu Cheng, Kuan Po Peng, Shuu Jiun Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Migraine is associated with syncope. We investigated risk factors for syncope and burden of syncope in migraine patients. Methods: Participants were recruited from a headache clinic. All participants provided information on lifestyle, co-morbidity, syncope, headache and suicide, and completed the MIDAS and HADS questionnaires. Genetic data were available for a subset of participants. Risk of syncope in relation to participant’s characteristics and migraine susceptibility loci, and risks of psychological disorders associated with syncope, were calculated using logistic regression. Results: Underweight, regular tea intake, diabetes mellitus, and migraine with aura were associated with increased syncope risks, with adjusted ORs of 1.76 (95% CI 1.03–3.03), 1.84 (95% CI 1.22–2.79), 4.70 (95% CI 1.58–13.95), and 1.78 (95% CI 1.03–3.10), respectively. Preliminary results showed that rs11172113 in LRP1 was associated with syncope risks. Comorbid syncope in migraine patients was associated with increased risks of depression (OR 1.95, 95% CI 1.18–3.22) and suicide attempt (OR 2.85, 95% CI 1.48–5.48). Conclusion: Our study showed the potential roles of vascular risk factors in the association between migraine and syncope. Modifiable risk factors for syncope in patients with migraine include body mass index and tea intake. The debilitating psychological impact of co-morbid syncope in migraine patients warrants clinical attention of treating physicians.

Original languageEnglish
Pages (from-to)1838-1846
Number of pages9
Issue number14
StatePublished - 1 Dec 2019


  • depression
  • diabetes mellitus
  • Low Density Lipoprotein Receptor-Related Protein-1
  • LRP1
  • Migraine
  • migraine with aura
  • suicide
  • syncope
  • tea
  • underweight


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