Revisiting the quantitative features of surface-assisted laser desorption/ionization mass spectrometric analysis

Ching Yi Wu, Kai Chieh Lee, Yen Ling Kuo, Yu-Chie Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Surface-assisted laser desorption/ionization (SALDi) coupled with mass spectrometry (MS) is frequently used to analyse small organics owing to its clean background. Inorganic materials can be used as energy absorbers and the transfer medium to facilitate the desorption/ionization of analytes; thus, they are used as SALDi-assisting materials. Many studies have demonstrated the usefulness of SALDi-MS in quantitative analysis of small organics. However, some characteristics occurring in SALDi-MS require certain attention to ensure the reliability of the quantitative analysis results. The appearance of a coffee-ring effect in SALDi sample preparation is the primary factor that can affect quantitative SALDi-MS analysis results. However, to the best of our knowledge, there are no reports relating to quantitative SALDi-MS analysis that discuss or consider this effect. In this study, the coffee-ring effect is discussed using nanoparticles and nanostructured substrates as SALDi-assisting materials to show how this effect influences SALDi-MS analysis results. Potential solutions for overcoming the existing problems are also suggested.

Original languageEnglish
Article number20150379
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Issue number2079
StatePublished - 28 Oct 2016


  • Mass spectrometry
  • Mass spectrometry imaging
  • Quantitative analysis
  • Surface-assisted laser desorption/ionization
  • Titania nanotubes


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