Reversible cerebral vasoconstriction syndrome: Current and future perspectives

Shih Pin Chen, Jong Ling Fuh, Shuu Jiun Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations


Reversible cerebral vasoconstriction syndromes (RCVS) are characterized by recurrent acute severe headaches, namely thunderclap headaches, and multifocal segmental vasoconstrictions. Interest has arisen in the definitions, clinical presentations, differential diagnoses, risk factors and complications of RCVS. This article will comprehensively review the milestone monographs and the latest research work addressing these issues. Studies that have focused on the relationship between RCVS and thunderclap headache will be detailed. We will also discuss research on the enigmatic pathophysiology and potential therapeutic approaches. Up-to-date information and challenges, undergoing studies and future research directions will be deeply probed.

Original languageEnglish
Pages (from-to)1265-1276
Number of pages12
JournalExpert Review of Neurotherapeutics
Issue number9
StatePublished - Sep 2011


  • posterior reversible encephalopathy syndrome
  • reversible cerebral vasoconstriction syndromes
  • thunderclap headache


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