Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke

I. Kuan Wang; Chung Hsiang Liu; Tzung Hai Yen; Jiann Shing Jeng; Sheng Feng Sung; Pai Hao Huang; Jie Yuan Li; Yu Sun; Cheng Yu Wei; Li Ming Lien; I. Ju Tsai; Fung Chang Sung; Chung Y. Hsu; Chung Hsiang Liu; Chon Haw Tsai; Wei Shih Huang; Chung Ta Lu; Tzung Chang Tsai; Chun Hung Tseng; Kang Hsu Lin; Woei Cherng Shyu; Yu Wan Yang; Yen Liang Liu; Der Yang Cho; Chun Chung Chen; Sung Chun Tang; Li Kai Tsai; Shin Joe Yeh; Chih Hao Chen; Hsin Hsi Tsai; Han Jung Chen; Kan Lu; Shih Pin Hsu; Hung Chang Kuo; Jung Chi Tsou; Yan Tang Wang; Yi Cheng Tai; Meng Tsang Hsieh; Po Chao Liliang; Cheng Loong Liang; Hao Kuang Wang; Yu Tun Tsai; Kuo Wei Wang; Jui Sheng Chen; Po Yuan Chen; Yi Ching Wang; Pi Shan Sung; Han Chieh Hsieh; Hui Chen Su; Hou Chang Chiu; Wei Hung Chen; Chyi Huey Bai; Tzu Hsuan Huang; Chi Ieong Lau; Ya Ying Wu; Hsu Ling Yeh; Anna Chang; Ching Huang Lin; Cheng Chang Yen; Ruey Tay Lin; Gim Thean Khor; A. Ching Chao; Hsiu Fen Lin; Poyin Huang; Huey Juan Lin; Der Shin Ke; Chia Yu Chang; Poh Shiow Yeh; Kao Chang Lin; Tain Junn Cheng; Chih Ho Chou; Chun Ming Yang; Hsiu Chu Shen; An Chih Chen; Shih Jei Tsai; Tsong Ming Lu; Sheng Ling Kung; Mei Ju Lee; Hsi Hsien Chou; Wei Lun Chang; Pai Yi Chiu; Min Hsien Hsu; Po Chi Chan; Chau Hsiung Pan; Hai Ming Shoung; Yi Chen Lo; Fu Hwa Wang; Wei Chieh Chang; Ta Chang Lai; Jiu Haw Yin; Chung Jen Wang; Kai Chen Wang; Li Mei Chen; Jong Chyou Denq; Chien Jung Lu; Chieh Cheng Huang; Hoi Fong Chan; Siu Pak Lee; Ming Hui Sun; Li Ying Ke; Po Lin Chen; Yu Shan Lee; Cheung Ter Ong; Chi Shun Wu; Yung Chu Hsu; Yu Hsiang Su; Ling Chien Hung; Jiunn Tay Lee; Jiann Chyun Lin; Yaw Don Hsu; Giia Sheun Peng; Chang Hung Hsu; Chun Chieh Lin; Che Hung Yen; Chun An Cheng; Yueh Feng Sung; Yuan Liang Chen; Ming Tung Lien; Chia Chen Liu; Fu Chi Yang; Yi Chung Wu; An Chen Tso; Yu Hua Lai; Chun I. Chiang; Chia Kuang Tsai; Meng Ta Liu; Ying Che Lin; Tsuey Ru Chiang; Pin Wen Liao; Mei Ching Lee; Jen Tse Chen; Sian King Lie; Mu Chien Sun; Pi Ju Hsiao; Wei Liang Chen; Ta Cheng Chen; Chen Shu Chang; Chien Hsu Lai; Chieh Sen Chuang; Yen Yu Chen; Shinn Kuang Lin; Yu Chin Su; Jen Lun Shiao; Fu Yi Yang; Chih Yang Liu; Han Lin Chiang; Guei Chiuan Chen; Po Jen Hsu; I. sheng Lin; Chung Hsien Chien; Yang Chuang Chang; Ping Kun Chen; Yu Jen Hsiao; Chen Wen Fang; Yu Wei Chen; Kuo Ying Lee; Yun Yu Lin; Chen Hua Li; Hui Fen Tsai; Chuan Fa Hsieh; Chih Dong Yang; Shiumn Jen Liaw; How Chin Liao; Ling Li Wu; Liang Po Hsieh; Yong Hui Lee; Chung Wen Chen; Chih Shan Hsu; Ye Jian Jhih; Hao Yu Zhuang; Yan Hong Pan; Shin An Shih; Chin I. Chen; Jia Ying Sung; Hsing Yu Weng; Hao Wen Teng; Jing Er Lee; Chih Shan Huang; Shu Ping Chao; Rey Yue Yuan; Jau Jiuan Sheu; Jia Ming Yu; Chun Sum Ho; Ting Chun Lin; Shih Chieh Yu; Jiunn Rong Chen; Song Yen Tsai; Cheng Yu Wei; Chao Hsien Hung; Chia Fang Lee; Sheng Kung Yang; Chih Lin Chen; Wei Lin; Hung Pin Tseng; Chun Liang Lin; Hung Chih Lin; Pi Tzu Chen; Chaur Jong Hu; Lung Chan; Nai Fang Chi; Chang Ming Chern; Chun Jen Lin; Shuu Jiun Wang; Li Chi Hsu; Wen Jang Wong; I. Hui Lee; Der Jen Yen; Ching Piao Tsai; Shang Yeong Kwan; Bing Wen Soong; Shih Pin Chen; Kwong Kum Liao; Kung Ping Lin; Chien Chen; Din E. Shan; Jong Ling Fuh; Pei Ning Wang; Yi Chung Lee; Yu Hsiang Yu; Hui Chi Huang; Jui Yao Tsai; Ming Hsiu Wu; Szu Yi Chiang; Chiung Yao Wang; Ming Chin Hsu; Po Yen Yeh; Ko Yi Wang; Tsang Shan Chen; Cheng Yang Hsieh; Wei Fen Chen; Ping Keung Yip; Vinchi Wang; Chung Fen Tsai; Chao Ching Chen; Yi Chien Liu; Shao Yuan Chen; Zi Hao Zhao; Zhi Peng Wei; Shey Lin Wu; Ching Kuan Liu; Ryh Huei Lin; Ching Hua Chu; Sui Hing Yan; Sheng Huang Hsiao; Bak Sau Yip; Pei Chun Tsai; Ping Chen Chou; Tsam Ming Kuo; Yi Pin Chiu; Kun Chang Tsai; Yi Sheng Liao; Ming Jun Tsai; Hsin Yi Kao

doi:10.1016/j.atherosclerosis.2017.11.029

Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke

I. Kuan Wang, Chung Hsiang Liu, Tzung Hai Yen, Jiann Shing Jeng, Sheng Feng Sung, Pai Hao Huang, Jie Yuan Li, Yu Sun, Cheng Yu Wei, Li Ming Lien, I. Ju Tsai, Fung Chang Sung^*, Chung Y. Hsu, Chung Hsiang Liu, Chon Haw Tsai, Wei Shih Huang, Chung Ta Lu, Tzung Chang Tsai, Chun Hung Tseng, Kang Hsu LinWoei Cherng Shyu, Yu Wan Yang, Yen Liang Liu, Der Yang Cho, Chun Chung Chen, Sung Chun Tang, Li Kai Tsai, Shin Joe Yeh, Chih Hao Chen, Hsin Hsi Tsai, Han Jung Chen, Kan Lu, Shih Pin Hsu, Hung Chang Kuo, Jung Chi Tsou, Yan Tang Wang, Yi Cheng Tai, Meng Tsang Hsieh, Po Chao Liliang, Cheng Loong Liang, Hao Kuang Wang, Yu Tun Tsai, Kuo Wei Wang, Jui Sheng Chen, Po Yuan Chen, Yi Ching Wang, Pi Shan Sung, Han Chieh Hsieh, Hui Chen Su, Hou Chang Chiu, Wei Hung Chen, Chyi Huey Bai, Tzu Hsuan Huang, Chi Ieong Lau, Ya Ying Wu, Hsu Ling Yeh, Anna Chang, Ching Huang Lin, Cheng Chang Yen, Ruey Tay Lin, Gim Thean Khor, A. Ching Chao, Hsiu Fen Lin, Poyin Huang, Huey Juan Lin, Der Shin Ke, Chia Yu Chang, Poh Shiow Yeh, Kao Chang Lin, Tain Junn Cheng, Chih Ho Chou, Chun Ming Yang, Hsiu Chu Shen, An Chih Chen, Shih Jei Tsai, Tsong Ming Lu, Sheng Ling Kung, Mei Ju Lee, Hsi Hsien Chou, Wei Lun Chang, Pai Yi Chiu, Min Hsien Hsu, Po Chi Chan, Chau Hsiung Pan, Hai Ming Shoung, Yi Chen Lo, Fu Hwa Wang, Wei Chieh Chang, Ta Chang Lai, Jiu Haw Yin, Chung Jen Wang, Kai Chen Wang, Li Mei Chen, Jong Chyou Denq, Chien Jung Lu, Chieh Cheng Huang, Hoi Fong Chan, Siu Pak Lee, Ming Hui Sun, Li Ying Ke, Po Lin Chen, Yu Shan Lee, Cheung Ter Ong, Chi Shun Wu, Yung Chu Hsu, Yu Hsiang Su, Ling Chien Hung, Jiunn Tay Lee, Jiann Chyun Lin, Yaw Don Hsu, Giia Sheun Peng, Chang Hung Hsu, Chun Chieh Lin, Che Hung Yen, Chun An Cheng, Yueh Feng Sung, Yuan Liang Chen, Ming Tung Lien, Chia Chen Liu, Fu Chi Yang, Yi Chung Wu, An Chen Tso, Yu Hua Lai, Chun I. Chiang, Chia Kuang Tsai, Meng Ta Liu, Ying Che Lin, Tsuey Ru Chiang, Pin Wen Liao, Mei Ching Lee, Jen Tse Chen, Sian King Lie, Mu Chien Sun, Pi Ju Hsiao, Wei Liang Chen, Ta Cheng Chen, Chen Shu Chang, Chien Hsu Lai, Chieh Sen Chuang, Yen Yu Chen, Shinn Kuang Lin, Yu Chin Su, Jen Lun Shiao, Fu Yi Yang, Chih Yang Liu, Han Lin Chiang, Guei Chiuan Chen, Po Jen Hsu, I. sheng Lin, Chung Hsien Chien, Yang Chuang Chang, Ping Kun Chen, Yu Jen Hsiao, Chen Wen Fang, Yu Wei Chen, Kuo Ying Lee, Yun Yu Lin, Chen Hua Li, Hui Fen Tsai, Chuan Fa Hsieh, Chih Dong Yang, Shiumn Jen Liaw, How Chin Liao, Ling Li Wu, Liang Po Hsieh, Yong Hui Lee, Chung Wen Chen, Chih Shan Hsu, Ye Jian Jhih, Hao Yu Zhuang, Yan Hong Pan, Shin An Shih, Chin I. Chen, Jia Ying Sung, Hsing Yu Weng, Hao Wen Teng, Jing Er Lee, Chih Shan Huang, Shu Ping Chao, Rey Yue Yuan, Jau Jiuan Sheu, Jia Ming Yu, Chun Sum Ho, Ting Chun Lin, Shih Chieh Yu, Jiunn Rong Chen, Song Yen Tsai, Cheng Yu Wei, Chao Hsien Hung, Chia Fang Lee, Sheng Kung Yang, Chih Lin Chen, Wei Lin, Hung Pin Tseng, Chun Liang Lin, Hung Chih Lin, Pi Tzu Chen, Chaur Jong Hu, Lung Chan, Nai Fang Chi, Chang Ming Chern, Chun Jen Lin, Shuu Jiun Wang, Li Chi Hsu, Wen Jang Wong, I. Hui Lee, Der Jen Yen, Ching Piao Tsai, Shang Yeong Kwan, Bing Wen Soong, Shih Pin Chen, Kwong Kum Liao, Kung Ping Lin, Chien Chen, Din E. Shan, Jong Ling Fuh, Pei Ning Wang, Yi Chung Lee, Yu Hsiang Yu, Hui Chi Huang, Jui Yao Tsai, Ming Hsiu Wu, Szu Yi Chiang, Chiung Yao Wang, Ming Chin Hsu, Po Yen Yeh, Ko Yi Wang, Tsang Shan Chen, Cheng Yang Hsieh, Wei Fen Chen, Ping Keung Yip, Vinchi Wang, Chung Fen Tsai, Chao Ching Chen, Yi Chien Liu, Shao Yuan Chen, Zi Hao Zhao, Zhi Peng Wei, Shey Lin Wu, Ching Kuan Liu, Ryh Huei Lin, Ching Hua Chu, Sui Hing Yan, Sheng Huang Hsiao, Bak Sau Yip, Pei Chun Tsai, Ping Chen Chou, Tsam Ming Kuo, Yi Pin Chiu, Kun Chang Tsai, Yi Sheng Liao, Ming Jun Tsai, Hsin Yi Kao

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m² or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m² or dialysis than in patients with eGFR ≥90 mL/min/1.73 m² (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m² to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m² or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m² to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m² or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m². Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.

Original language	English
Pages (from-to)	288-293
Number of pages	6
Journal	Atherosclerosis
Volume	269
DOIs	https://doi.org/10.1016/j.atherosclerosis.2017.11.029
State	Published - 1 Feb 2018

Keywords

Estimated glomerular filtration rate
Ischemic stroke
Mortality
Renal function

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.atherosclerosis.2017.11.029

Cite this

Wang, I. K., Liu, C. H., Yen, T. H., Jeng, J. S., Sung, S. F., Huang, P. H., Li, J. Y., Sun, Y., Wei, C. Y., Lien, L. M., Tsai, I. J., Sung, F. C., Hsu, C. Y., Liu, C. H., Tsai, C. H., Huang, W. S., Lu, C. T., Tsai, T. C., Tseng, C. H., ... Kao, H. Y. (2018). Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke. Atherosclerosis, 269, 288-293. https://doi.org/10.1016/j.atherosclerosis.2017.11.029

@article{7bdbab815a55496b8781b59f79620b0c,

title = "Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke",

abstract = "Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m2 or dialysis than in patients with eGFR ≥90 mL/min/1.73 m2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m2. Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.",

keywords = "Estimated glomerular filtration rate, Ischemic stroke, Mortality, Renal function",

author = "Wang, {I. Kuan} and Liu, {Chung Hsiang} and Yen, {Tzung Hai} and Jeng, {Jiann Shing} and Sung, {Sheng Feng} and Huang, {Pai Hao} and Li, {Jie Yuan} and Yu Sun and Wei, {Cheng Yu} and Lien, {Li Ming} and Tsai, {I. Ju} and Sung, {Fung Chang} and Hsu, {Chung Y.} and Liu, {Chung Hsiang} and Tsai, {Chon Haw} and Huang, {Wei Shih} and Lu, {Chung Ta} and Tsai, {Tzung Chang} and Tseng, {Chun Hung} and Lin, {Kang Hsu} and Shyu, {Woei Cherng} and Yang, {Yu Wan} and Liu, {Yen Liang} and Cho, {Der Yang} and Chen, {Chun Chung} and Tang, {Sung Chun} and Tsai, {Li Kai} and Yeh, {Shin Joe} and Chen, {Chih Hao} and Tsai, {Hsin Hsi} and Chen, {Han Jung} and Kan Lu and Hsu, {Shih Pin} and Kuo, {Hung Chang} and Tsou, {Jung Chi} and Wang, {Yan Tang} and Tai, {Yi Cheng} and Hsieh, {Meng Tsang} and Liliang, {Po Chao} and Liang, {Cheng Loong} and Wang, {Hao Kuang} and Tsai, {Yu Tun} and Wang, {Kuo Wei} and Chen, {Jui Sheng} and Chen, {Po Yuan} and Wang, {Yi Ching} and Sung, {Pi Shan} and Hsieh, {Han Chieh} and Su, {Hui Chen} and Chiu, {Hou Chang} and Chen, {Wei Hung} and Bai, {Chyi Huey} and Huang, {Tzu Hsuan} and Lau, {Chi Ieong} and Wu, {Ya Ying} and Yeh, {Hsu Ling} and Anna Chang and Lin, {Ching Huang} and Yen, {Cheng Chang} and Lin, {Ruey Tay} and Khor, {Gim Thean} and Chao, {A. Ching} and Lin, {Hsiu Fen} and Poyin Huang and Lin, {Huey Juan} and Ke, {Der Shin} and Chang, {Chia Yu} and Yeh, {Poh Shiow} and Lin, {Kao Chang} and Cheng, {Tain Junn} and Chou, {Chih Ho} and Yang, {Chun Ming} and Shen, {Hsiu Chu} and Chen, {An Chih} and Tsai, {Shih Jei} and Lu, {Tsong Ming} and Kung, {Sheng Ling} and Lee, {Mei Ju} and Chou, {Hsi Hsien} and Chang, {Wei Lun} and Chiu, {Pai Yi} and Hsu, {Min Hsien} and Chan, {Po Chi} and Pan, {Chau Hsiung} and Shoung, {Hai Ming} and Lo, {Yi Chen} and Wang, {Fu Hwa} and Chang, {Wei Chieh} and Lai, {Ta Chang} and Yin, {Jiu Haw} and Wang, {Chung Jen} and Wang, {Kai Chen} and Chen, {Li Mei} and Denq, {Jong Chyou} and Lu, {Chien Jung} and Huang, {Chieh Cheng} and Chan, {Hoi Fong} and Lee, {Siu Pak} and Sun, {Ming Hui} and Ke, {Li Ying} and Chen, {Po Lin} and Lee, {Yu Shan} and Ong, {Cheung Ter} and Wu, {Chi Shun} and Hsu, {Yung Chu} and Su, {Yu Hsiang} and Hung, {Ling Chien} and Lee, {Jiunn Tay} and Lin, {Jiann Chyun} and Hsu, {Yaw Don} and Peng, {Giia Sheun} and Hsu, {Chang Hung} and Lin, {Chun Chieh} and Yen, {Che Hung} and Cheng, {Chun An} and Sung, {Yueh Feng} and Chen, {Yuan Liang} and Lien, {Ming Tung} and Liu, {Chia Chen} and Yang, {Fu Chi} and Wu, {Yi Chung} and Tso, {An Chen} and Lai, {Yu Hua} and Chiang, {Chun I.} and Tsai, {Chia Kuang} and Liu, {Meng Ta} and Lin, {Ying Che} and Chiang, {Tsuey Ru} and Liao, {Pin Wen} and Lee, {Mei Ching} and Chen, {Jen Tse} and Lie, {Sian King} and Sun, {Mu Chien} and Hsiao, {Pi Ju} and Chen, {Wei Liang} and Chen, {Ta Cheng} and Chang, {Chen Shu} and Lai, {Chien Hsu} and Chuang, {Chieh Sen} and Chen, {Yen Yu} and Lin, {Shinn Kuang} and Su, {Yu Chin} and Shiao, {Jen Lun} and Yang, {Fu Yi} and Liu, {Chih Yang} and Chiang, {Han Lin} and Chen, {Guei Chiuan} and Hsu, {Po Jen} and Lin, {I. sheng} and Chien, {Chung Hsien} and Chang, {Yang Chuang} and Chen, {Ping Kun} and Hsiao, {Yu Jen} and Fang, {Chen Wen} and Chen, {Yu Wei} and Lee, {Kuo Ying} and Lin, {Yun Yu} and Li, {Chen Hua} and Tsai, {Hui Fen} and Hsieh, {Chuan Fa} and Yang, {Chih Dong} and Liaw, {Shiumn Jen} and Liao, {How Chin} and Wu, {Ling Li} and Hsieh, {Liang Po} and Lee, {Yong Hui} and Chen, {Chung Wen} and Hsu, {Chih Shan} and Jhih, {Ye Jian} and Zhuang, {Hao Yu} and Pan, {Yan Hong} and Shih, {Shin An} and Chen, {Chin I.} and Sung, {Jia Ying} and Weng, {Hsing Yu} and Teng, {Hao Wen} and Lee, {Jing Er} and Huang, {Chih Shan} and Chao, {Shu Ping} and Yuan, {Rey Yue} and Sheu, {Jau Jiuan} and Yu, {Jia Ming} and Ho, {Chun Sum} and Lin, {Ting Chun} and Yu, {Shih Chieh} and Chen, {Jiunn Rong} and Tsai, {Song Yen} and Wei, {Cheng Yu} and Hung, {Chao Hsien} and Lee, {Chia Fang} and Yang, {Sheng Kung} and Chen, {Chih Lin} and Wei Lin and Tseng, {Hung Pin} and Lin, {Chun Liang} and Lin, {Hung Chih} and Chen, {Pi Tzu} and Hu, {Chaur Jong} and Lung Chan and Chi, {Nai Fang} and Chern, {Chang Ming} and Lin, {Chun Jen} and Wang, {Shuu Jiun} and Hsu, {Li Chi} and Wong, {Wen Jang} and Lee, {I. Hui} and Yen, {Der Jen} and Tsai, {Ching Piao} and Kwan, {Shang Yeong} and Soong, {Bing Wen} and Chen, {Shih Pin} and Liao, {Kwong Kum} and Lin, {Kung Ping} and Chien Chen and Shan, {Din E.} and Fuh, {Jong Ling} and Wang, {Pei Ning} and Lee, {Yi Chung} and Yu, {Yu Hsiang} and Huang, {Hui Chi} and Tsai, {Jui Yao} and Wu, {Ming Hsiu} and Chiang, {Szu Yi} and Wang, {Chiung Yao} and Hsu, {Ming Chin} and Yeh, {Po Yen} and Wang, {Ko Yi} and Chen, {Tsang Shan} and Hsieh, {Cheng Yang} and Chen, {Wei Fen} and Yip, {Ping Keung} and Vinchi Wang and Tsai, {Chung Fen} and Chen, {Chao Ching} and Liu, {Yi Chien} and Chen, {Shao Yuan} and Zhao, {Zi Hao} and Wei, {Zhi Peng} and Wu, {Shey Lin} and Liu, {Ching Kuan} and Lin, {Ryh Huei} and Chu, {Ching Hua} and Yan, {Sui Hing} and Hsiao, {Sheng Huang} and Yip, {Bak Sau} and Tsai, {Pei Chun} and Chou, {Ping Chen} and Kuo, {Tsam Ming} and Chiu, {Yi Pin} and Tsai, {Kun Chang} and Liao, {Yi Sheng} and Tsai, {Ming Jun} and Kao, {Hsin Yi}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2018",

month = feb,

day = "1",

doi = "10.1016/j.atherosclerosis.2017.11.029",

language = "English",

volume = "269",

pages = "288--293",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

}

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TY - JOUR

T1 - Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke

AU - Wang, I. Kuan

AU - Liu, Chung Hsiang

AU - Yen, Tzung Hai

AU - Jeng, Jiann Shing

AU - Sung, Sheng Feng

AU - Huang, Pai Hao

AU - Li, Jie Yuan

AU - Sun, Yu

AU - Wei, Cheng Yu

AU - Lien, Li Ming

AU - Tsai, I. Ju

AU - Sung, Fung Chang

AU - Hsu, Chung Y.

AU - Liu, Chung Hsiang

AU - Tsai, Chon Haw

AU - Huang, Wei Shih

AU - Lu, Chung Ta

AU - Tsai, Tzung Chang

AU - Tseng, Chun Hung

AU - Lin, Kang Hsu

AU - Shyu, Woei Cherng

AU - Yang, Yu Wan

AU - Liu, Yen Liang

AU - Cho, Der Yang

AU - Chen, Chun Chung

AU - Tang, Sung Chun

AU - Tsai, Li Kai

AU - Yeh, Shin Joe

AU - Chen, Chih Hao

AU - Tsai, Hsin Hsi

AU - Chen, Han Jung

AU - Lu, Kan

AU - Hsu, Shih Pin

AU - Kuo, Hung Chang

AU - Tsou, Jung Chi

AU - Wang, Yan Tang

AU - Tai, Yi Cheng

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AU - Lee, I. Hui

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AU - Shan, Din E.

AU - Fuh, Jong Ling

AU - Wang, Pei Ning

AU - Lee, Yi Chung

AU - Yu, Yu Hsiang

AU - Huang, Hui Chi

AU - Tsai, Jui Yao

AU - Wu, Ming Hsiu

AU - Chiang, Szu Yi

AU - Wang, Chiung Yao

AU - Hsu, Ming Chin

AU - Yeh, Po Yen

AU - Wang, Ko Yi

AU - Chen, Tsang Shan

AU - Hsieh, Cheng Yang

AU - Chen, Wei Fen

AU - Yip, Ping Keung

AU - Wang, Vinchi

AU - Tsai, Chung Fen

AU - Chen, Chao Ching

AU - Liu, Yi Chien

AU - Chen, Shao Yuan

AU - Zhao, Zi Hao

AU - Wei, Zhi Peng

AU - Wu, Shey Lin

AU - Liu, Ching Kuan

AU - Lin, Ryh Huei

AU - Chu, Ching Hua

AU - Yan, Sui Hing

AU - Hsiao, Sheng Huang

AU - Yip, Bak Sau

AU - Tsai, Pei Chun

AU - Chou, Ping Chen

AU - Kuo, Tsam Ming

AU - Chiu, Yi Pin

AU - Tsai, Kun Chang

AU - Liao, Yi Sheng

AU - Tsai, Ming Jun

AU - Kao, Hsin Yi

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m2 or dialysis than in patients with eGFR ≥90 mL/min/1.73 m2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m2. Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.

AB - Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m2 or dialysis than in patients with eGFR ≥90 mL/min/1.73 m2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m2. Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.

KW - Estimated glomerular filtration rate

KW - Ischemic stroke

KW - Mortality

KW - Renal function

UR - http://www.scopus.com/inward/record.url?scp=85039456839&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2017.11.029

DO - 10.1016/j.atherosclerosis.2017.11.029

M3 - Article

C2 - 29254692

AN - SCOPUS:85039456839

SN - 0021-9150

VL - 269

SP - 288

EP - 293

JO - Atherosclerosis

JF - Atherosclerosis

ER -

Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke

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