Renal artery involvement in acute aortic dissection: Prevalence and impact on renal atrophy in non-interventional treatment patients

Chun Chieh Wang, Huey Shyan Lin, Yi Luan Huang, Fu Zong Wu, Chiung Chen Chuo, Yu Jeng Ju, Carol C. Wu, Ming Ting Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: To evaluate the frequency of renal artery dissection (RAD) and renal hypoperfusion in aortic dissection (AD) and its effect on subsequent renal atrophy in patients who did not undergo therapeutic intervention. Methods: Initial CT data of 155 patients with acute AD (Stanford type A = 88, B = 67) were retrospectively analyzed. The false lumen statuses were patent (n = 94), partially thrombosed (n = 25), and completely thrombosed (n = 36) (also called as intramural hematoma (IMH)). Follow-up CT images of the surviving 122 patients (6–62.6 months, median, 28.9 months) were reviewed for analysis of sequential changes in renal volume. A regional decrease of ≧20 Hounsfield units in the renal cortex was defined as a renal hypo-enhancement sign (RHS). Simplified CT estimations of renal volume and estimated glomerular filtration rates (eGFR) were calculated. The generalized estimating equations (GEE) method was used to predict renal atrophy. Results: Fifty of the 122 patients presented with 59 RAD in the current study, and a positive RHS was noted in 33.9% (20/59) of these involved kidneys. GEE analysis showed hypertension, surgical treatment for AD, presence of RAD, and positive RHS as significant risk factors for renal atrophy. Patients with RHS had the most severe form of renal atrophy. The severity of renal atrophy was mildly correlated with GFR change (γ2 = 0.044, p < 0.001). Conclusion: Renal atrophy in AD was predicted by the CT findings of RAD and RHS. The severity of renal atrophy was weakly reflected by eGFR.

Original languageEnglish
Pages (from-to)404-410
Number of pages7
JournalJournal of Cardiovascular Computed Tomography
Volume12
Issue number5
DOIs
StatePublished - 1 Sep 2018

Keywords

  • Aortic dissection
  • Generalized estimating equation
  • Malperfusion
  • Multidetector computed tomography
  • Renal atrophy

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