Regulation of CD8+ T cell functions by RARγ

Claire Gordy, Ivan Dzhagalov, You Wen He*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Retinoic acid plays a key role in the development and function of the immune system; however, the contribution of each of the three retinoic acid receptors (RARs) to the T cell immune response is not yet well understood. Of these receptors, both RARα and RARγ are expressed in T lymphocytes. While possible functional redundancy thus complicates understanding of the role of each receptor in T cells, emerging data suggest that RARα and RARγ function differently in thymocyte development and that RARγ is required for both primary and secondary CD8+ T cell immune responses.

Original languageEnglish
Pages (from-to)2-7
Number of pages6
JournalSeminars in Immunology
Volume21
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • CD8 T lymphocytes
  • Retinoic acid receptor γ

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