Abstract
Retinoic acid plays a key role in the development and function of the immune system; however, the contribution of each of the three retinoic acid receptors (RARs) to the T cell immune response is not yet well understood. Of these receptors, both RARα and RARγ are expressed in T lymphocytes. While possible functional redundancy thus complicates understanding of the role of each receptor in T cells, emerging data suggest that RARα and RARγ function differently in thymocyte development and that RARγ is required for both primary and secondary CD8+ T cell immune responses.
Original language | English |
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Pages (from-to) | 2-7 |
Number of pages | 6 |
Journal | Seminars in Immunology |
Volume | 21 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2009 |
Keywords
- CD8 T lymphocytes
- Retinoic acid receptor γ