Regulation of aging and age-related disease by DAF-16 and heat-shock factor

Ao Lin Hsu; Coleen T. Murphy; Cynthia Kenyon

doi:10.1126/science.1083701

Regulation of aging and age-related disease by DAF-16 and heat-shock factor

Ao Lin Hsu, Coleen T. Murphy, Cynthia Kenyon^*

^*Corresponding author for this work

National Yang Ming Chiao Tung University

Research output: Contribution to journal › Article › peer-review

1210 Scopus citations

Abstract

The Caenorhabditis elegans transcription factor HSF-1, which regulates the heatshock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and shortens life-span, and we show that hsf-1 overexpression extends lifespan. We find that HSF-1, like the transcription factor DAF-16, is required for daf-2-insulin/IGF-1 receptor mutations to extend life-span. Our findings suggest this is because HSF-1 and DAF-16 together activate expression of specific genes, including genes encoding small heat-shock proteins, which in turn promote longevity. The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease.

Original language	English
Pages (from-to)	1142-1145
Number of pages	4
Journal	Science
Volume	300
Issue number	5622
DOIs	https://doi.org/10.1126/science.1083701
State	Published - 16 May 2003

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abstract = "The Caenorhabditis elegans transcription factor HSF-1, which regulates the heatshock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and shortens life-span, and we show that hsf-1 overexpression extends lifespan. We find that HSF-1, like the transcription factor DAF-16, is required for daf-2-insulin/IGF-1 receptor mutations to extend life-span. Our findings suggest this is because HSF-1 and DAF-16 together activate expression of specific genes, including genes encoding small heat-shock proteins, which in turn promote longevity. The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease.",

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AB - The Caenorhabditis elegans transcription factor HSF-1, which regulates the heatshock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and shortens life-span, and we show that hsf-1 overexpression extends lifespan. We find that HSF-1, like the transcription factor DAF-16, is required for daf-2-insulin/IGF-1 receptor mutations to extend life-span. Our findings suggest this is because HSF-1 and DAF-16 together activate expression of specific genes, including genes encoding small heat-shock proteins, which in turn promote longevity. The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease.

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Regulation of aging and age-related disease by DAF-16 and heat-shock factor

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