Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

Priscilla Cheung; Jordi Xiol; Michael T. Dill; Wei Chien Yuan; Riccardo Panero; Jatin Roper; Fernando G. Osorio; Dejan Maglic; Qi Li; Basanta Gurung; Raffaele A. Calogero; Ömer H. Yilmaz; Junhao Mao; Fernando D. Camargo

doi:10.1016/j.stem.2020.07.003

Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

Priscilla Cheung, Jordi Xiol, Michael T. Dill, Wei Chien Yuan, Riccardo Panero, Jatin Roper, Fernando G. Osorio, Dejan Maglic, Qi Li, Basanta Gurung, Raffaele A. Calogero, Ömer H. Yilmaz, Junhao Mao, Fernando D. Camargo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Hippo inhibition reprograms intestinal stem cells (ISCs) to a wound-healing-like cell state that can be induced to suppress tumorigenesis in human and mouse metastatic colorectal cancer.

Original language	English
Pages (from-to)	590-604.e9
Journal	Cell Stem Cell
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2020.07.003
State	Published - 1 Oct 2020

Keywords

Hippo signaling
Wnt signaling
colorectal cancer
intestinal stem cells
metastasis
regeneration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.stem.2020.07.003

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Cheung, P., Xiol, J., Dill, M. T., Yuan, W. C., Panero, R., Roper, J., Osorio, F. G., Maglic, D., Li, Q., Gurung, B., Calogero, R. A., Yilmaz, Ö. H., Mao, J., & Camargo, F. D. (2020). Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. Cell Stem Cell, 27(4), 590-604.e9. https://doi.org/10.1016/j.stem.2020.07.003

@article{a81377c6af1f41aeb56a8bcc0b85f7dd,

title = "Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer",

abstract = "Hippo inhibition reprograms intestinal stem cells (ISCs) to a wound-healing-like cell state that can be induced to suppress tumorigenesis in human and mouse metastatic colorectal cancer.",

keywords = "Hippo signaling, Wnt signaling, colorectal cancer, intestinal stem cells, metastasis, regeneration",

author = "Priscilla Cheung and Jordi Xiol and Dill, {Michael T.} and Yuan, {Wei Chien} and Riccardo Panero and Jatin Roper and Osorio, {Fernando G.} and Dejan Maglic and Qi Li and Basanta Gurung and Calogero, {Raffaele A.} and Yilmaz, {{\"O}mer H.} and Junhao Mao and Camargo, {Fernando D.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = oct,

day = "1",

doi = "10.1016/j.stem.2020.07.003",

language = "English",

volume = "27",

pages = "590--604.e9",

journal = "Cell Stem Cell",

issn = "1934-5909",

publisher = "Cell Press",

number = "4",

}

Cheung, P, Xiol, J, Dill, MT, Yuan, WC, Panero, R, Roper, J, Osorio, FG, Maglic, D, Li, Q, Gurung, B, Calogero, RA, Yilmaz, ÖH, Mao, J & Camargo, FD 2020, 'Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer', Cell Stem Cell, vol. 27, no. 4, pp. 590-604.e9. https://doi.org/10.1016/j.stem.2020.07.003

TY - JOUR

T1 - Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

AU - Cheung, Priscilla

AU - Xiol, Jordi

AU - Dill, Michael T.

AU - Yuan, Wei Chien

AU - Panero, Riccardo

AU - Roper, Jatin

AU - Osorio, Fernando G.

AU - Maglic, Dejan

AU - Li, Qi

AU - Gurung, Basanta

AU - Calogero, Raffaele A.

AU - Yilmaz, Ömer H.

AU - Mao, Junhao

AU - Camargo, Fernando D.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Hippo inhibition reprograms intestinal stem cells (ISCs) to a wound-healing-like cell state that can be induced to suppress tumorigenesis in human and mouse metastatic colorectal cancer.

AB - Hippo inhibition reprograms intestinal stem cells (ISCs) to a wound-healing-like cell state that can be induced to suppress tumorigenesis in human and mouse metastatic colorectal cancer.

KW - Hippo signaling

KW - Wnt signaling

KW - colorectal cancer

KW - intestinal stem cells

KW - metastasis

KW - regeneration

UR - http://www.scopus.com/inward/record.url?scp=85089380385&partnerID=8YFLogxK

U2 - 10.1016/j.stem.2020.07.003

DO - 10.1016/j.stem.2020.07.003

M3 - Article

C2 - 32730753

AN - SCOPUS:85089380385

SN - 1934-5909

VL - 27

SP - 590-604.e9

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 4

ER -

Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

Abstract

Keywords

UN SDGs

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