Reduction in the retinotopic early visual cortex with normal aging and magnitude of perceptual learning

Li Hung Chang, Yuko Yotsumoto, David H. Salat, George J. Andersen, Takeo Watanabe, Yuka Sasaki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Although normal aging is known to reduce cortical structures globally, the effects of aging on local structures and functions of early visual cortex are less understood. Here, using standard retinotopic mapping and magnetic resonance imaging morphologic analyses, we investigated whether aging affects areal size of the early visual cortex, which were retinotopically localized, and whether those morphologic measures were associated with individual performance on visual perceptual learning. First, significant age-associated reduction was found in the areal size of V1, V2, and V3. Second, individual ability of visual perceptual learning was significantly correlated with areal size of V3 in older adults. These results demonstrate that aging changes local structures of the early visual cortex, and the degree of change may be associated with individual visual plasticity.

Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalNeurobiology of Aging
Volume36
Issue number1
DOIs
StatePublished - 1 Jan 2015

Keywords

  • Aging
  • Cortical surface size
  • Early visual area
  • Perceptual learning
  • Retinotopic mapping

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