TY - GEN
T1 - Red blood cell deformability upon continuous or repetitive loadings
AU - Ito, Hiroaki
AU - Murakami, Ryo
AU - Tsai, Chia-Hung
AU - Horade, Mitsuhiro
AU - Tanaka, Motomu
AU - Kaneko, Makoto
PY - 2017/2/23
Y1 - 2017/2/23
N2 - This paper focuses on the comparison of red blood cell (RBC) deformability under continuous and repetitive loadings. We utilized a feedback position-control system and a narrow microfluidic channel for applying different deformation patterns on RBCs. According to the analyses of shape recoveries with different patterns, we found, for the first time, that the mechanical responses of RBCs upon continuous and repetitive loadings are almost the same within the error among cellular individualities as long as the total duration of the loading is the same. The result indicates that the internal mechanical stress on RBCs accumulates even if the apparent cell shape recovers. The finding provides quantitative insights for the systematic comparison among various exisiting measurement methods of mechanical responses of cells.
AB - This paper focuses on the comparison of red blood cell (RBC) deformability under continuous and repetitive loadings. We utilized a feedback position-control system and a narrow microfluidic channel for applying different deformation patterns on RBCs. According to the analyses of shape recoveries with different patterns, we found, for the first time, that the mechanical responses of RBCs upon continuous and repetitive loadings are almost the same within the error among cellular individualities as long as the total duration of the loading is the same. The result indicates that the internal mechanical stress on RBCs accumulates even if the apparent cell shape recovers. The finding provides quantitative insights for the systematic comparison among various exisiting measurement methods of mechanical responses of cells.
UR - http://www.scopus.com/inward/record.url?scp=85015733372&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2017.7863360
DO - 10.1109/MEMSYS.2017.7863360
M3 - Conference contribution
AN - SCOPUS:85015733372
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 141
EP - 144
BT - 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017
Y2 - 22 January 2017 through 26 January 2017
ER -