Recent advances in D-A-D based Pdots with NIR-II fluorescence for deep-tissue imaging

Partha Chowdhury; Yang Hsiang Chan

doi:10.1039/d2me00034b

Recent advances in D-A-D based Pdots with NIR-II fluorescence for deep-tissue imaging

Partha Chowdhury, Yang Hsiang Chan^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

In recent years, semiconducting polymer-based nanoparticles (Pdots) emitting in the second near-infrared window (NIR-II, 1000-1700 nm) have become a promising type of ultrabright fluorescence probe benefitting from numerous advantages in the NIR-II region, including reduced photon scattering, minimal tissue autofluorescence, and deep-tissue penetration. Among the diverse types of NIR-II fluorescent Pdots, donor-acceptor-donor (D-A-D)-based Pdots exhibit superior properties over others, especially for their high fluorescent brightness and excellent photostability. This mini-review article focuses on the recent development of D-A-D based Pdots emitting in the NIR-II window and their diverse applications in deep-tissue in vivo imaging. Finally, an outlook is given for the future designs of bright NIR-II D-A-D Pdots.

Original language	English
Pages (from-to)	702-719
Number of pages	18
Journal	Molecular Systems Design and Engineering
Volume	7
Issue number	7
DOIs	https://doi.org/10.1039/d2me00034b
State	Published - 8 Apr 2022

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title = "Recent advances in D-A-D based Pdots with NIR-II fluorescence for deep-tissue imaging",

abstract = "In recent years, semiconducting polymer-based nanoparticles (Pdots) emitting in the second near-infrared window (NIR-II, 1000-1700 nm) have become a promising type of ultrabright fluorescence probe benefitting from numerous advantages in the NIR-II region, including reduced photon scattering, minimal tissue autofluorescence, and deep-tissue penetration. Among the diverse types of NIR-II fluorescent Pdots, donor-acceptor-donor (D-A-D)-based Pdots exhibit superior properties over others, especially for their high fluorescent brightness and excellent photostability. This mini-review article focuses on the recent development of D-A-D based Pdots emitting in the NIR-II window and their diverse applications in deep-tissue in vivo imaging. Finally, an outlook is given for the future designs of bright NIR-II D-A-D Pdots.",

author = "Partha Chowdhury and Chan, {Yang Hsiang}",

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AU - Chowdhury, Partha

AU - Chan, Yang Hsiang

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N2 - In recent years, semiconducting polymer-based nanoparticles (Pdots) emitting in the second near-infrared window (NIR-II, 1000-1700 nm) have become a promising type of ultrabright fluorescence probe benefitting from numerous advantages in the NIR-II region, including reduced photon scattering, minimal tissue autofluorescence, and deep-tissue penetration. Among the diverse types of NIR-II fluorescent Pdots, donor-acceptor-donor (D-A-D)-based Pdots exhibit superior properties over others, especially for their high fluorescent brightness and excellent photostability. This mini-review article focuses on the recent development of D-A-D based Pdots emitting in the NIR-II window and their diverse applications in deep-tissue in vivo imaging. Finally, an outlook is given for the future designs of bright NIR-II D-A-D Pdots.

AB - In recent years, semiconducting polymer-based nanoparticles (Pdots) emitting in the second near-infrared window (NIR-II, 1000-1700 nm) have become a promising type of ultrabright fluorescence probe benefitting from numerous advantages in the NIR-II region, including reduced photon scattering, minimal tissue autofluorescence, and deep-tissue penetration. Among the diverse types of NIR-II fluorescent Pdots, donor-acceptor-donor (D-A-D)-based Pdots exhibit superior properties over others, especially for their high fluorescent brightness and excellent photostability. This mini-review article focuses on the recent development of D-A-D based Pdots emitting in the NIR-II window and their diverse applications in deep-tissue in vivo imaging. Finally, an outlook is given for the future designs of bright NIR-II D-A-D Pdots.

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DO - 10.1039/d2me00034b

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Recent advances in D-A-D based Pdots with NIR-II fluorescence for deep-tissue imaging

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