Rates of behavior and aging specified by mitochondrial function during development

Andrew Dillin; Ao Lin Hsu; Nuno Arantes-Oliveira; Joshua Lehrer-Graiwer; Honor Hsin; Andrew G. Fraser; Ravi S. Kamath; Julie Ahringer; Cynthia Kenyon

doi:10.1126/science.1077780

Rates of behavior and aging specified by mitochondrial function during development

Andrew Dillin, Ao Lin Hsu, Nuno Arantes-Oliveira, Joshua Lehrer-Graiwer, Honor Hsin, Andrew G. Fraser, Ravi S. Kamath, Julie Ahringer, Cynthia Kenyon^*

^*Corresponding author for this work

Institute of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

863 Scopus citations

Abstract

To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5′-triphosphate (ATP) synthase with RNA interference (RNAi) in Caenorhabditis elegans. These perturbations reduced body size and behavioral rates and extended adult life-span. Restoring messenger RNA to near-normal levels during adulthood did not elevate ATP levels and did not correct any of these phenotypes. Conversely, inhibiting respiratory-chain components during adulthood only did not reset behavioral rates and did not affect life-span. Thus, the developing animal appears to contain a regulatory system that monitors mitochondrial activity early in life and, in response, establishes rates of respiration, behavior, and aging that persist during adulthood.

Original language	English
Pages (from-to)	2398-2401
Number of pages	4
Journal	Science
Volume	298
Issue number	5602
DOIs	https://doi.org/10.1126/science.1077780
State	Published - 20 Dec 2002

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title = "Rates of behavior and aging specified by mitochondrial function during development",

abstract = "To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5′-triphosphate (ATP) synthase with RNA interference (RNAi) in Caenorhabditis elegans. These perturbations reduced body size and behavioral rates and extended adult life-span. Restoring messenger RNA to near-normal levels during adulthood did not elevate ATP levels and did not correct any of these phenotypes. Conversely, inhibiting respiratory-chain components during adulthood only did not reset behavioral rates and did not affect life-span. Thus, the developing animal appears to contain a regulatory system that monitors mitochondrial activity early in life and, in response, establishes rates of respiration, behavior, and aging that persist during adulthood.",

author = "Andrew Dillin and Hsu, {Ao Lin} and Nuno Arantes-Oliveira and Joshua Lehrer-Graiwer and Honor Hsin and Fraser, {Andrew G.} and Kamath, {Ravi S.} and Julie Ahringer and Cynthia Kenyon",

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AU - Dillin, Andrew

AU - Hsu, Ao Lin

AU - Arantes-Oliveira, Nuno

AU - Lehrer-Graiwer, Joshua

AU - Hsin, Honor

AU - Fraser, Andrew G.

AU - Kamath, Ravi S.

AU - Ahringer, Julie

AU - Kenyon, Cynthia

PY - 2002/12/20

Y1 - 2002/12/20

N2 - To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5′-triphosphate (ATP) synthase with RNA interference (RNAi) in Caenorhabditis elegans. These perturbations reduced body size and behavioral rates and extended adult life-span. Restoring messenger RNA to near-normal levels during adulthood did not elevate ATP levels and did not correct any of these phenotypes. Conversely, inhibiting respiratory-chain components during adulthood only did not reset behavioral rates and did not affect life-span. Thus, the developing animal appears to contain a regulatory system that monitors mitochondrial activity early in life and, in response, establishes rates of respiration, behavior, and aging that persist during adulthood.

AB - To explore the role of mitochondrial activity in the aging process, we have lowered the activity of the electron transport chain and adenosine 5′-triphosphate (ATP) synthase with RNA interference (RNAi) in Caenorhabditis elegans. These perturbations reduced body size and behavioral rates and extended adult life-span. Restoring messenger RNA to near-normal levels during adulthood did not elevate ATP levels and did not correct any of these phenotypes. Conversely, inhibiting respiratory-chain components during adulthood only did not reset behavioral rates and did not affect life-span. Thus, the developing animal appears to contain a regulatory system that monitors mitochondrial activity early in life and, in response, establishes rates of respiration, behavior, and aging that persist during adulthood.

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Rates of behavior and aging specified by mitochondrial function during development

Abstract

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