Rapid divergence in expression between duplicate genes inferred from microarray data

Zhenglong Gu*, Dan Nicolae, Henry H.S. Lu, Wen Hsiung Li

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

250 Scopus citations

Abstract

For more than 30 years, expression divergence has been considered as a major reason for retaining duplicated genes in a genome, but how often and how fast duplicate genes diverge in expression has not been studied at the genomic level. Using yeast microarray data, we show that expression divergence between duplicate genes is significantly correlated with their synonymous divergence (KS) and also with their nonsynonymous divergence (KA) if KA ≤ 0.3. Thus, expression divergence increases with evolutionary time, and KA is initially coupled with expression divergence. More interestingly, a large proportion of duplicate genes have diverged quickly in expression and the vast majority of gene pairs eventually become divergent in expression. Indeed, more than 40% of gene pairs show expression divergence even when KS is ≤ 0.10, and this proportion becomes >80% for KS > 1.5. Only a small fraction of ancient gene pairs do not show expression divergence.

Original languageEnglish
Article numberPII S0168-9525(02)02837-8
Pages (from-to)609-613
Number of pages5
JournalTrends in Genetics
Volume18
Issue number12
DOIs
StatePublished - 1 Dec 2002

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